Gene description for FBXW4
Gene name F-box and WD repeat domain containing 4
Gene symbol FBXW4
Other names/aliases DAC
FBW4
FBWD4
SHFM3
SHSF3
Species Homo sapiens
 Database cross references - FBXW4
ExoCarta ExoCarta_6468
Entrez Gene 6468
HGNC 10847
MIM 608071
UniProt P57775  
 FBXW4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FBXW4
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    embryonic limb morphogenesis GO:0030326 NAS
    embryonic digit morphogenesis GO:0042733 IEA
    cartilage development GO:0051216 IEA
    Wnt signaling pathway GO:0016055 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 NAS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 NAS
 Experiment description of studies that identified FBXW4 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FBXW4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FBXW4 is involved
PathwayEvidenceSource
Association of TriC/CCT with target proteins during biosynthesis TAS Reactome





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