Gene description for COPS7A
Gene name COP9 signalosome subunit 7A
Gene symbol COPS7A
Other names/aliases CSN7
CSN7A
SGN7a
Species Homo sapiens
 Database cross references - COPS7A
ExoCarta ExoCarta_50813
Vesiclepedia VP_50813
Entrez Gene 50813
HGNC 16758
MIM 616009
UniProt Q9UBW8  
 COPS7A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for COPS7A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein deneddylation GO:0000338 IDA
    COP9 signalosome assembly GO:0010387 IEA
    protein neddylation GO:0045116 NAS
    regulation of protein neddylation GO:2000434 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 IPI
 Experiment description of studies that identified COPS7A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COPS7A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Affinity Capture-MS Homo sapiens
2 DENR 8562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PQBP1  
Affinity Capture-MS Homo sapiens
4 NUF2  
Affinity Capture-MS Homo sapiens
5 ARHGEF2 9181
Co-fractionation Homo sapiens
6 FAM98A 25940
Affinity Capture-MS Homo sapiens
7 FBXO7 25793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RAB40AL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 UBE2M 9040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TNRC18  
Affinity Capture-MS Homo sapiens
11 VPRBP 9730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 Cul3  
Affinity Capture-MS Mus musculus
14 HSP90AB1 3326
Co-fractionation Homo sapiens
15 CSNK2A1 1457
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
16 ANKRD39  
Affinity Capture-MS Homo sapiens
17 SOX2  
Affinity Capture-MS Homo sapiens
18 PMF1  
Two-hybrid Homo sapiens
19 MYEOV2 150678
Affinity Capture-MS Homo sapiens
20 KIAA1429 25962
Affinity Capture-MS Homo sapiens
21 FBXW4 6468
Affinity Capture-MS Homo sapiens
22 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CORO1B 57175
Affinity Capture-MS Homo sapiens
25 PTGS2 5743
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
26 SYCE3  
Affinity Capture-MS Homo sapiens
27 FBXO17 115290
Affinity Capture-MS Homo sapiens
28 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 COPS6 10980
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 Dtl  
Affinity Capture-MS Mus musculus
31 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 NFE2L2 4780
Reconstituted Complex Homo sapiens
33 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
34 PSMD12 5718
Co-fractionation Homo sapiens
35 SYT2  
Affinity Capture-MS Homo sapiens
36 PLCG1 5335
Co-fractionation Homo sapiens
37 TOM1L1 10040
Two-hybrid Homo sapiens
38 LRR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HSPA6 3310
Co-fractionation Homo sapiens
40 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 BTRC 8945
Affinity Capture-Western Homo sapiens
42 GPS1 2873
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
43 HRASLS2  
Affinity Capture-MS Homo sapiens
44 CSNK2B 1460
Far Western Homo sapiens
45 BTBD10 84280
Affinity Capture-MS Homo sapiens
46 FBXL5  
Affinity Capture-MS Homo sapiens
47 AP5S1  
Affinity Capture-MS Homo sapiens
48 SRP9 6726
Affinity Capture-MS Homo sapiens
49 ATP5A1 498
Co-fractionation Homo sapiens
50 CDC23 8697
Affinity Capture-MS Homo sapiens
51 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 Ddb1 13194
Affinity Capture-MS Mus musculus
53 MAPRE1 22919
Affinity Capture-Western Homo sapiens
54 PPBP 5473
Two-hybrid Homo sapiens
55 MYH9 4627
Co-fractionation Homo sapiens
56 VCP 7415
Affinity Capture-MS Homo sapiens
57 DTL  
Affinity Capture-MS Homo sapiens
58 SAR1B 51128
Affinity Capture-MS Homo sapiens
59 DCAF10  
Affinity Capture-MS Homo sapiens
60 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
61 ANAPC4 29945
Affinity Capture-MS Homo sapiens
62 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 COPS7B 64708
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Synthetic Lethality Homo sapiens
64 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CT45A5  
Affinity Capture-MS Homo sapiens
66 COPS8 10920
Co-purification Homo sapiens
Far Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 HSPA5 3309
Co-fractionation Homo sapiens
68 COPS2 9318
Far Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
69 ERCC8  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
70 USP15 9958
Affinity Capture-Western Homo sapiens
71 CSN2 1447
Affinity Capture-MS Homo sapiens
72 CCDC82  
Affinity Capture-MS Homo sapiens
73 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ASB6 140459
Affinity Capture-MS Homo sapiens
75 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
76 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
77 CTTN 2017
Co-fractionation Homo sapiens
78 PRKD1 5587
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
79 FBXO6 26270
Affinity Capture-MS Homo sapiens
80 EIF2S2 8894
Affinity Capture-MS Homo sapiens
81 POLR2A 5430
Co-fractionation Homo sapiens
82 KLHL13 90293
Affinity Capture-MS Homo sapiens
83 DCAF8 50717
Co-fractionation Homo sapiens
84 PRMT5 10419
Co-fractionation Homo sapiens
85 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
86 IRF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
87 NLRP3  
Affinity Capture-MS Homo sapiens
88 RHOBTB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 JUNB  
Affinity Capture-MS Homo sapiens
90 TCEB2 6923
Affinity Capture-MS Homo sapiens
91 RAF1 5894
Two-hybrid Homo sapiens
92 KLHL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 DET1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 Cul4a  
Affinity Capture-MS Mus musculus
95 EPB41L1 2036
Co-fractionation Homo sapiens
96 CT45A1  
Affinity Capture-MS Homo sapiens
97 GRK5 2869
Affinity Capture-MS Homo sapiens
98 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
99 FBXW11  
Affinity Capture-MS Homo sapiens
100 RAD17  
Affinity Capture-MS Homo sapiens
101 WDR77 79084
Co-fractionation Homo sapiens
102 FBXL6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
103 TP53 7157
Co-fractionation Homo sapiens
104 COPS4 51138
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
105 RFWD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SLX4IP  
Affinity Capture-MS Homo sapiens
107 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 FBXL14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 IKBKB 3551
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
110 RPS4X 6191
Cross-Linking-MS (XL-MS) Homo sapiens
111 DCAF11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 APBB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 EPB41L2 2037
Co-fractionation Homo sapiens
114 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
115 BTBD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 DDIT3 1649
Affinity Capture-Western Homo sapiens
117 CSN1S1 1446
Affinity Capture-MS Homo sapiens
118 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 DCAF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 ISL2  
Affinity Capture-MS Homo sapiens
121 Sept9  
Affinity Capture-MS Mus musculus
122 RPA3 6119
Proximity Label-MS Homo sapiens
123 KCTD20 222658
Affinity Capture-MS Homo sapiens
124 NEDD8 4738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 CSN3 1448
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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