Gene description for CSN2
Gene name casein beta
Gene symbol CSN2
Other names/aliases CASB
Species Homo sapiens
 Database cross references - CSN2
ExoCarta ExoCarta_1447
Entrez Gene 1447
HGNC 2447
MIM 115460
UniProt P05814  
 CSN2 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for CSN2
Molecular Function
    calcium ion binding GO:0005509 TAS
    enzyme inhibitor activity GO:0004857 TAS
    transporter activity GO:0005215 IEA
Biological Process
    negative regulation of lactation GO:1903488 IBA
    calcium ion transport GO:0006816 TAS
    negative regulation of catalytic activity GO:0043086 TAS
    lactation GO:0007595 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CSN2 in exosomes
Experiment ID 46
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CSN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NEK1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CSN2 is involved
Nuclear signaling by ERBB4 TAS Reactome

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