Gene description for CSN2
Gene name casein beta
Gene symbol CSN2
Other names/aliases CASB
Species Homo sapiens
 Database cross references - CSN2
ExoCarta ExoCarta_1447
Vesiclepedia VP_1447
Entrez Gene 1447
HGNC 2447
MIM 115460
UniProt P05814  
 CSN2 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for CSN2
Molecular Function
    enzyme inhibitor activity GO:0004857 TAS
    cysteine-type endopeptidase inhibitor activity GO:0004869 IDA
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
Biological Process
    calcium ion transport GO:0006816 TAS
    lactation GO:0007595 IDA
    negative regulation of cysteine-type endopeptidase activity GO:2000117 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CSN2 in exosomes
1
Experiment ID 46
MISEV standards
EM|IEM
Biophysical techniques
HSC70|CD63|MHCII|CD81|CD86
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for CSN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARRB2 409
Affinity Capture-MS Homo sapiens
2 PPP3R1 5534
Affinity Capture-MS Homo sapiens
3 USE1 55850
Affinity Capture-MS Homo sapiens
4 CSNK2B 1460
Biochemical Activity Homo sapiens
5 COPS7A 50813
Affinity Capture-MS Homo sapiens
6 GRB2 2885
Two-hybrid Homo sapiens
7 HTRA2 27429
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
8 AURKA 6790
Biochemical Activity Homo sapiens
9 UBQLN2 29978
Two-hybrid Homo sapiens
10 TOLLIP 54472
Two-hybrid Homo sapiens
11 NFYC 4802
Two-hybrid Homo sapiens
12 NHLRC2 374354
Affinity Capture-MS Homo sapiens
13 CSNK2A1 1457
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
14 CUL4B 8450
Affinity Capture-MS Homo sapiens
15 CUL1 8454
Affinity Capture-Western Homo sapiens
16 CDK1 983
Biochemical Activity Homo sapiens
17 CDC42 998
Two-hybrid Homo sapiens
18 CRYBB3  
Affinity Capture-MS Homo sapiens
19 NEK2  
Biochemical Activity Homo sapiens
20 ARHGAP36  
Affinity Capture-MS Homo sapiens
21 CORO2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ARRB1 408
Affinity Capture-MS Homo sapiens
23 PLK1 5347
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
24 PIPOX  
Affinity Capture-MS Homo sapiens
25 PPP3CC 5533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RAC1 5879
Two-hybrid Homo sapiens
27 FHL2 2274
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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