Gene description for FBXO17
Gene name F-box protein 17
Gene symbol FBXO17
Other names/aliases FBG4
FBX26
FBXO26
Fbx17
Species Homo sapiens
 Database cross references - FBXO17
ExoCarta ExoCarta_115290
Vesiclepedia VP_115290
Entrez Gene 115290
HGNC 18754
MIM 609094
UniProt Q96EF6  
 FBXO17 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FBXO17
Molecular Function
    protein binding GO:0005515 IDA
    protein binding GO:0005515 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    glycoprotein catabolic process GO:0006516 IBA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA
    ERAD pathway GO:0036503 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    SCF ubiquitin ligase complex GO:0019005 IBA
    SCF ubiquitin ligase complex GO:0019005 IDA
 Experiment description of studies that identified FBXO17 in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DZIP3  
Two-hybrid Homo sapiens
2 CDCA8 55143
Two-hybrid Homo sapiens
3 FBXW2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NMT1 4836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 COPS2 9318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 COPS7A 50813
Affinity Capture-MS Homo sapiens
8 C11orf52 91894
Proximity Label-MS Homo sapiens
9 METTL7A 25840
Proximity Label-MS Homo sapiens
10 DDX58 23586
Affinity Capture-RNA Homo sapiens
11 HSPA8 3312
Affinity Capture-MS Homo sapiens
12 FAM154A  
Two-hybrid Homo sapiens
13 CLPP 8192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RUNX1  
Two-hybrid Homo sapiens
15 ADAMTSL4  
Two-hybrid Homo sapiens
16 SPERT  
Two-hybrid Homo sapiens
17 ADRB2  
Two-hybrid Homo sapiens
18 CUL5 8065
Affinity Capture-MS Homo sapiens
19 COPS8 10920
Affinity Capture-MS Homo sapiens
20 SKP1 6500
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 JRK  
Two-hybrid Homo sapiens
22 ZSCAN9  
Two-hybrid Homo sapiens
23 USP54 159195
Two-hybrid Homo sapiens
24 ZNF829  
Two-hybrid Homo sapiens
25 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
26 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
27 OAS2 4939
Two-hybrid Homo sapiens
28 KRTAP13-2  
Two-hybrid Homo sapiens
29 MYEOV2 150678
Affinity Capture-MS Homo sapiens
30 BLK 640
Affinity Capture-MS Homo sapiens
31 EIF4H 7458
Two-hybrid Homo sapiens
32 GPS1 2873
Affinity Capture-MS Homo sapiens
33 NDUFA2 4695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RPA3 6119
Proximity Label-MS Homo sapiens
35 ANKRD39  
Affinity Capture-MS Homo sapiens
36 SARS2 54938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 FAM154B  
Two-hybrid Homo sapiens
38 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KRT75 9119
Two-hybrid Homo sapiens
40 RAB11FIP2  
Two-hybrid Homo sapiens
41 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 NMT2 9397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 COPS4 51138
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 COPS7B 64708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KPRP 448834
Two-hybrid Homo sapiens
49 TATDN1 83940
Affinity Capture-MS Homo sapiens
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