Gene description for OAS2
Gene name 2'-5'-oligoadenylate synthetase 2, 69/71kDa
Gene symbol OAS2
Other names/aliases -
Species Homo sapiens
 Database cross references - OAS2
ExoCarta ExoCarta_4939
Entrez Gene 4939
HGNC 8087
MIM 603350
UniProt P29728  
 OAS2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for OAS2
Molecular Function
    2'-5'-oligoadenylate synthetase activity GO:0001730 IMP
    metal ion binding GO:0046872 IEA
    double-stranded RNA binding GO:0003725 IMP
    ATP binding GO:0005524 IMP
    zinc ion binding GO:0008270 IDA
    protein binding GO:0005515 IPI
Biological Process
    response to virus GO:0009615 TAS
    type I interferon signaling pathway GO:0060337 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    defense response to virus GO:0051607 IEA
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    RNA catabolic process GO:0006401 IEA
    protein myristoylation GO:0018377 IMP
    protein glycosylation GO:0006486 IDA
    purine nucleotide biosynthetic process GO:0006164 IDA
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    mitochondrion GO:0005739 IEA
    intracellular membrane-bounded organelle GO:0043231 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IEA
    membrane GO:0016020 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified OAS2 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OAS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OAS2 is involved
Interferon alpha/beta signaling TAS Reactome
Interferon gamma signaling TAS Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here