Gene description for PRKG1
Gene name protein kinase, cGMP-dependent, type I
Gene symbol PRKG1
Other names/aliases 1
AAT8
PKG
PRKG1B
PRKGR1B
cGK
cGK 1
cGK1
cGKI
cGKI-BETA
cGKI-alpha
Species Homo sapiens
 Database cross references - PRKG1
ExoCarta ExoCarta_5592
Vesiclepedia VP_5592
Entrez Gene 5592
HGNC 9414
MIM 176894
UniProt Q13976  
 PRKG1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PRKG1
Molecular Function
    calcium channel regulator activity GO:0005246 IDA
    cGMP-dependent protein kinase activity GO:0004692 IDA
    ATP binding GO:0005524 IEA
    cGMP binding GO:0030553 IEA
    protein binding GO:0005515 IPI
Biological Process
    actin cytoskeleton organization GO:0030036 TAS
    neuron migration GO:0001764 IEA
    blood coagulation GO:0007596 TAS
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    dendrite development GO:0016358 IEA
    protein phosphorylation GO:0006468 IEA
    negative regulation of platelet aggregation GO:0090331 IMP
    relaxation of vascular smooth muscle GO:0060087 IEA
    cGMP-mediated signaling GO:0019934 IEA
    regulation of GTPase activity GO:0043087 IMP
    signal transduction GO:0007165 TAS
    forebrain development GO:0030900 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified PRKG1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PRKG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITPR1 3708
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
2 PPP1R12B 4660
Two-hybrid Homo sapiens
3 RAF1 5894
Affinity Capture-Western Homo sapiens
4 PPP1R12A 4659
Reconstituted Complex Homo sapiens
5 RGS2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 GAPDH 2597
Affinity Capture-Western Homo sapiens
7 NPR1 4881
Two-hybrid Homo sapiens
8 MRVI1 10335
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
9 TNNT1  
Invivo Homo sapiens
Invitro Homo sapiens
10 GTF2I 2969
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PRKG1 is involved
PathwayEvidenceSource
Ca2+ pathway TAS Reactome





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