Gene description for SELL
Gene name selectin L
Gene symbol SELL
Other names/aliases CD62L
LAM1
LECAM1
LEU8
LNHR
LSEL
LYAM1
PLNHR
TQ1
Species Homo sapiens
 Database cross references - SELL
ExoCarta ExoCarta_6402
Entrez Gene 6402
HGNC 10720
MIM 153240
UniProt P14151  
 SELL identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SELL
Molecular Function
    cell adhesion molecule binding GO:0050839 IEA
    glycosphingolipid binding GO:0043208 TAS
    protease binding GO:0002020 IPI
    carbohydrate binding GO:0030246 IEA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 TAS
Biological Process
    cell adhesion GO:0007155 IEA
    regulation of immune response GO:0050776 TAS
    leukocyte migration GO:0050900 TAS
    response to ATP GO:0033198 IEA
    blood coagulation GO:0007596 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified SELL in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SELL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PODXL2  
Reconstituted Complex Homo sapiens
2 CD4 920
Invitro Homo sapiens
3 EZR 7430
Invitro Homo sapiens
4 EMCN  
Affinity Capture-Western Homo sapiens
5 SELPLG 6404
Invivo Homo sapiens
Invitro Homo sapiens
6 MSN 4478
Invitro Homo sapiens
7 PODXL 5420
Affinity Capture-Western Homo sapiens
8 CFH 3075
Reconstituted Complex Homo sapiens
9 GRB2 2885
Affinity Capture-Western Homo sapiens
10 MUC7 4589
Reconstituted Complex Homo sapiens
11 SELE  
Invitro Homo sapiens
View the network image/svg+xml



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