Gene description for SELL
Gene name selectin L
Gene symbol SELL
Other names/aliases CD62L
LAM1
LECAM1
LEU8
LNHR
LSEL
LYAM1
PLNHR
TQ1
Species Homo sapiens
 Database cross references - SELL
ExoCarta ExoCarta_6402
Vesiclepedia VP_6402
Entrez Gene 6402
HGNC 10720
MIM 153240
UniProt P14151  
 SELL identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SELL
Molecular Function
    protease binding GO:0002020 IPI
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 TAS
    carbohydrate binding GO:0030246 TAS
    sialic acid binding GO:0033691 IBA
    glycosphingolipid binding GO:0043208 TAS
    oligosaccharide binding GO:0070492 IBA
    oligosaccharide binding GO:0070492 IMP
Biological Process
    cell adhesion GO:0007155 TAS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IBA
    leukocyte cell-cell adhesion GO:0007159 TAS
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IMP
    response to cytokine GO:0034097 IBA
    leukocyte tethering or rolling GO:0050901 IBA
    leukocyte tethering or rolling GO:0050901 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    secretory granule membrane GO:0030667 TAS
 Experiment description of studies that identified SELL in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SELL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCAN 1462
Reconstituted Complex Homo sapiens
2 EZR 7430
Reconstituted Complex Homo sapiens
3 SELE  
Affinity Capture-Luminescence Homo sapiens
4 EMCN  
Affinity Capture-Western Homo sapiens
5 PRKCQ 5588
Reconstituted Complex Homo sapiens
6 MSN 4478
Reconstituted Complex Homo sapiens
7 PRKG1 5592
Biochemical Activity Homo sapiens
8 SLC30A2  
Two-hybrid Homo sapiens
9 CFH 3075
Reconstituted Complex Homo sapiens
10 GRB2 2885
Affinity Capture-Western Homo sapiens
11 PODXL2 50512
Reconstituted Complex Homo sapiens
12 MUC7 4589
Reconstituted Complex Homo sapiens
13 PRKCA 5578
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 PODXL 5420
Affinity Capture-Western Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



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