Gene description for NPR1
Gene name natriuretic peptide receptor 1
Gene symbol NPR1
Other names/aliases ANPRA
ANPa
GUC2A
GUCY2A
NPRA
Species Homo sapiens
 Database cross references - NPR1
ExoCarta ExoCarta_4881
Entrez Gene 4881
HGNC 7943
MIM 108960
UniProt P16066  
 NPR1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NPR1
Molecular Function
    hormone binding GO:0042562 IPI
    protein kinase binding GO:0019901 IEA
    natriuretic peptide receptor activity GO:0016941 IDA
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IEA
    G-protein coupled peptide receptor activity GO:0008528 NAS
    guanylate cyclase activity GO:0004383 IDA
    GTP binding GO:0005525 IEA
    peptide hormone binding GO:0017046 IEA
Biological Process
    positive regulation of renal sodium excretion GO:0035815 TAS
    receptor guanylyl cyclase signaling pathway GO:0007168 IDA
    negative regulation of cell growth GO:0030308 NAS
    positive regulation of cGMP biosynthetic process GO:0030828 IEA
    regulation of vasodilation GO:0042312 NAS
    G-protein coupled receptor signaling pathway GO:0007186 NAS
    negative regulation of smooth muscle cell proliferation GO:0048662 IEA
    cell surface receptor signaling pathway GO:0007166 NAS
    regulation of vascular permeability GO:0043114 TAS
    regulation of blood vessel size GO:0050880 IEA
    negative regulation of angiogenesis GO:0016525 TAS
    intracellular signal transduction GO:0035556 IEA
    regulation of blood pressure GO:0008217 NAS
    protein phosphorylation GO:0006468 IEA
    body fluid secretion GO:0007589 TAS
    cGMP biosynthetic process GO:0006182 IDA
    positive regulation of urine volume GO:0035810 TAS
    dopamine metabolic process GO:0042417 IEA
Subcellular Localization
    receptor complex GO:0043235 IDA
    integral component of plasma membrane GO:0005887 IC
    intracellular GO:0005622 IEA
 Experiment description of studies that identified NPR1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NPR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKG1  
Two-hybrid Homo sapiens
2 NPPA  
Invivo Homo sapiens
Invitro Homo sapiens
3 NPPB  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which NPR1 is involved
No pathways found





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