Gene description for NPR1
Gene name	natriuretic peptide receptor 1
Gene symbol	NPR1
Other names/aliases	ANPRA ANPa GUC2A GUCY2A NPRA
Species	Homo sapiens
Database cross references - NPR1
ExoCarta	ExoCarta_4881
Vesiclepedia	VP_4881
Entrez Gene	4881
HGNC	7943
MIM	108960
UniProt	P16066
NPR1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for NPR1

Molecular Function     peptide receptor activity GO:0001653 IBA     guanylate cyclase activity GO:0004383 IBA     guanylate cyclase activity GO:0004383 IDA     protein kinase activity GO:0004672 IEA     ATP binding GO:0005524 IEA     GTP binding GO:0005525 IEA     G protein-coupled peptide receptor activity GO:0008528 NAS     natriuretic peptide receptor activity GO:0016941 IDA     peptide hormone binding GO:0017046 IPI     hormone binding GO:0042562 IPI Biological Process     cGMP biosynthetic process GO:0006182 IBA     cGMP biosynthetic process GO:0006182 IDA     cell surface receptor signaling pathway GO:0007166 NAS     receptor guanylyl cyclase signaling pathway GO:0007168 IBA     receptor guanylyl cyclase signaling pathway GO:0007168 IDA     receptor guanylyl cyclase signaling pathway GO:0007168 ISS     G protein-coupled receptor signaling pathway GO:0007186 IEA     body fluid secretion GO:0007589 TAS     regulation of blood pressure GO:0008217 ISS     regulation of blood pressure GO:0008217 NAS     positive regulation of cGMP-mediated signaling GO:0010753 IEA     negative regulation of angiogenesis GO:0016525 TAS     cGMP-mediated signaling GO:0019934 IEA     negative regulation of cell growth GO:0030308 NAS     positive regulation of urine volume GO:0035810 TAS     positive regulation of renal sodium excretion GO:0035815 TAS     dopamine metabolic process GO:0042417 IEA     regulation of vascular permeability GO:0043114 TAS     negative regulation of smooth muscle cell proliferation GO:0048662 IEA     blood vessel diameter maintenance GO:0097746 NAS Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 TAS     receptor complex GO:0043235 IDA     ANPR-A receptor complex GO:1990620 ISS