Gene description for COPS7B
Gene name COP9 signalosome subunit 7B
Gene symbol COPS7B
Other names/aliases CSN7B
SGN7b
Species Homo sapiens
 Database cross references - COPS7B
ExoCarta ExoCarta_64708
Vesiclepedia VP_64708
Entrez Gene 64708
HGNC 16760
MIM 616010
UniProt Q9H9Q2  
 COPS7B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for COPS7B
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein deneddylation GO:0000338 IDA
    COP9 signalosome assembly GO:0010387 IEA
    regulation of protein neddylation GO:2000434 NAS
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 ISS
 Experiment description of studies that identified COPS7B in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COPS7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DENR 8562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 FAM98A 25940
Affinity Capture-MS Homo sapiens
3 HSPA6 3310
Co-fractionation Homo sapiens
4 UBE2M 9040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VPRBP 9730
Affinity Capture-MS Homo sapiens
6 DST 667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 USP24 23358
Co-fractionation Homo sapiens
8 HSP90AB1 3326
Co-fractionation Homo sapiens
9 PPIA 5478
Affinity Capture-MS Homo sapiens
10 ANKRD39  
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 MYEOV2 150678
Affinity Capture-MS Homo sapiens
13 KIAA1429 25962
Affinity Capture-MS Homo sapiens
14 FBXW4 6468
Affinity Capture-MS Homo sapiens
15 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DDA1  
Affinity Capture-MS Homo sapiens
17 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CPSF4  
Affinity Capture-MS Homo sapiens
20 CDK2AP1  
Affinity Capture-MS Homo sapiens
21 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FBXO17 115290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SYT2  
Affinity Capture-MS Homo sapiens
24 PLCG1 5335
Co-fractionation Homo sapiens
25 FBXO11  
Affinity Capture-MS Homo sapiens
26 LRR1  
Affinity Capture-MS Homo sapiens
27 SUN2 25777
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TULP3 7289
Affinity Capture-MS Homo sapiens
29 FBXO7 25793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GGACT 87769
Affinity Capture-MS Homo sapiens
31 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 BTRC 8945
Affinity Capture-Western Homo sapiens
33 GPS1 2873
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 Racgap1 26934
Affinity Capture-MS Mus musculus
35 HEXIM1 10614
Co-fractionation Homo sapiens
36 SPAG5 10615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 AP5S1  
Affinity Capture-MS Homo sapiens
38 DLD 1738
Affinity Capture-MS Homo sapiens
39 ATP5A1 498
Co-fractionation Homo sapiens
40 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 Ddb1 13194
Affinity Capture-MS Mus musculus
42 Taf15  
Affinity Capture-MS Mus musculus
43 Pfdn2  
Affinity Capture-MS Mus musculus
44 MYH9 4627
Co-fractionation Homo sapiens
45 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
46 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 BEX5  
Two-hybrid Homo sapiens
49 CT45A5  
Affinity Capture-MS Homo sapiens
50 CKMT1B 1159
Affinity Capture-MS Homo sapiens
51 COPS8 10920
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 MYH7B  
Affinity Capture-MS Homo sapiens
53 HSPA5 3309
Co-fractionation Homo sapiens
54 COPS2 9318
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 COPS7A 50813
Synthetic Lethality Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 YWHAZ 7534
Affinity Capture-MS Homo sapiens
58 USP15 9958
Affinity Capture-Western Homo sapiens
59 KNSTRN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ASPM 259266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ASB6 140459
Affinity Capture-MS Homo sapiens
62 ERCC8  
Affinity Capture-MS Homo sapiens
63 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
64 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MAP3K7  
Affinity Capture-MS Homo sapiens
67 ERP44 23071
Affinity Capture-MS Homo sapiens
68 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
69 RPA3 6119
Proximity Label-MS Homo sapiens
70 Tpx2  
Affinity Capture-MS Mus musculus
71 RHOBTB1  
Affinity Capture-MS Homo sapiens
72 JUNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 TCEB2 6923
Affinity Capture-MS Homo sapiens
74 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 KLHL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 HOGA1  
Affinity Capture-MS Homo sapiens
77 DET1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 UBE3A 7337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 Tubg1 103733
Affinity Capture-MS Mus musculus
80 FBXL6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
81 NMI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 HSPA12A 259217
Affinity Capture-MS Homo sapiens
83 RFWD2  
Affinity Capture-MS Homo sapiens
84 HECTD3 79654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 RAB40A  
Affinity Capture-MS Homo sapiens
86 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 SKP1 6500
Affinity Capture-MS Homo sapiens
88 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
89 DCAF11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 APBB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 EPB41L2 2037
Co-fractionation Homo sapiens
92 FEM1B 10116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 DDX58 23586
Affinity Capture-RNA Homo sapiens
94 RNF7  
Affinity Capture-MS Homo sapiens
95 APPBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 MIF 4282
Affinity Capture-MS Homo sapiens
97 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 BTBD2  
Affinity Capture-MS Homo sapiens
99 Srsf1 110809
Affinity Capture-MS Mus musculus
100 KLHDC3  
Affinity Capture-MS Homo sapiens
101 NEDD8 4738
Affinity Capture-MS Homo sapiens
102 SERBP1 26135
Affinity Capture-MS Homo sapiens
103 KRAS 3845
Affinity Capture-MS Homo sapiens
104 DCAF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 COPS4 51138
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 PRMT1 3276
Co-fractionation Homo sapiens
107 PCMT1 5110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ZZEF1 23140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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