Gene description for PTGS2
Gene name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene symbol PTGS2
Other names/aliases COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
Species Homo sapiens
 Database cross references - PTGS2
ExoCarta ExoCarta_5743
Vesiclepedia VP_5743
Entrez Gene 5743
HGNC 9605
MIM 600262
UniProt P35354  
 PTGS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTGS2
Molecular Function
    protein homodimerization activity GO:0042803 IEA
    arachidonate 15-lipoxygenase activity GO:0050473 TAS
    peroxidase activity GO:0004601 NAS
    lipid binding GO:0008289 IEA
    enzyme binding GO:0019899 IPI
    prostaglandin-endoperoxide synthase activity GO:0004666 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    heme binding GO:0020037 ISS
Biological Process
    inflammatory response GO:0006954 IEA
    positive regulation of synaptic plasticity GO:0031915 IEA
    decidualization GO:0046697 IEA
    positive regulation of fibroblast growth factor production GO:0090271 ISS
    regulation of blood pressure GO:0008217 ISS
    positive regulation of vascular endothelial growth factor production GO:0010575 ISS
    NAD metabolic process GO:0019674 TAS
    angiogenesis GO:0001525 IEA
    response to vitamin D GO:0033280 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    cellular response to UV GO:0034644 IEA
    positive regulation of transforming growth factor beta production GO:0071636 ISS
    arachidonic acid metabolic process GO:0019369 TAS
    cellular response to mechanical stimulus GO:0071260 IEA
    bone mineralization GO:0030282 IEA
    ovulation GO:0030728 IEA
    oxidation-reduction process GO:0055114 IEA
    positive regulation of fever generation GO:0031622 ISS
    embryo implantation GO:0007566 IEA
    response to estradiol GO:0032355 IEA
    regulation of inflammatory response GO:0050727 NAS
    response to fructose GO:0009750 IEA
    nicotinamide metabolic process GO:0006769 TAS
    positive regulation of NF-kappaB import into nucleus GO:0042346 IEA
    response to glucocorticoid GO:0051384 IEA
    response to lipopolysaccharide GO:0032496 IEA
    small molecule metabolic process GO:0044281 TAS
    negative regulation of smooth muscle contraction GO:0045986 IEA
    cellular response to hypoxia GO:0071456 IEP
    prostaglandin metabolic process GO:0006693 TAS
    lipoxygenase pathway GO:0019372 TAS
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISS
    hair cycle GO:0042633 IEA
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISS
    vitamin metabolic process GO:0006766 TAS
    negative regulation of calcium ion transport GO:0051926 IEA
    sensory perception of pain GO:0019233 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    response to manganese ion GO:0010042 IEA
    positive regulation of platelet-derived growth factor production GO:0090362 ISS
    response to lithium ion GO:0010226 IEA
    cyclooxygenase pathway GO:0019371 TAS
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    maintenance of blood-brain barrier GO:0035633 IEA
    positive regulation of brown fat cell differentiation GO:0090336 ISS
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    movement of cell or subcellular component GO:0006928 TAS
    brown fat cell differentiation GO:0050873 IEA
    prostaglandin biosynthetic process GO:0001516 NAS
    response to drug GO:0042493 IEA
    negative regulation of cell cycle GO:0045786 IEA
    positive regulation of vasoconstriction GO:0045907 IEA
    learning GO:0007612 IEA
    response to tumor necrosis factor GO:0034612 IEA
    water-soluble vitamin metabolic process GO:0006767 TAS
    cellular response to ATP GO:0071318 IEA
    response to fatty acid GO:0070542 IEA
    positive regulation of smooth muscle contraction GO:0045987 IEA
    negative regulation of synaptic transmission, dopaminergic GO:0032227 IEA
    memory GO:0007613 IEA
    response to oxidative stress GO:0006979 IEA
    positive regulation of prostaglandin biosynthetic process GO:0031394 NAS
Subcellular Localization
    nucleus GO:0005634 ISS
    neuron projection GO:0043005 IDA
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
    protein complex GO:0043234 IEA
    endoplasmic reticulum GO:0005783 IDA
    caveola GO:0005901 IEA
 Experiment description of studies that identified PTGS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTGS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 CAV1 857
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 NUCB1 4924
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
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