Gene description for VIMP
Gene name VCP-interacting membrane selenoprotein
Gene symbol VIMP
Other names/aliases AD-015
ADO15
SBBI8
SELS
SEPS1
Species Homo sapiens
 Database cross references - VIMP
ExoCarta ExoCarta_55829
Vesiclepedia VP_55829
Entrez Gene 55829
HGNC 30396
MIM 607918
UniProt Q9BQE4  
 VIMP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VIMP
Molecular Function
    enzyme binding GO:0019899 IPI
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 NAS
    selenium binding GO:0008430 IEA
    antioxidant activity GO:0016209 IDA
Biological Process
    negative regulation of glucose import GO:0046325 TAS
    response to glucose GO:0009749 IEP
    ER overload response GO:0006983 IMP
    regulation of nitric oxide metabolic process GO:0080164 IMP
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IDA
    negative regulation of interleukin-6 production GO:0032715 ISS
    cell redox homeostasis GO:0045454 IDA
    negative regulation of tumor necrosis factor production GO:0032720 ISS
    negative regulation of inflammatory response GO:0050728 IC
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    establishment of protein localization GO:0045184 TAS
    negative regulation of nitric-oxide synthase biosynthetic process GO:0051771 IMP
    response to redox state GO:0051775 IDA
    negative regulation of macrophage apoptotic process GO:2000110 IMP
    cellular response to oxidative stress GO:0034599 IMP
    negative regulation of glycogen biosynthetic process GO:0045719 TAS
    cellular response to insulin stimulus GO:0032869 TAS
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP
    cellular response to lipopolysaccharide GO:0071222 IMP
    regulation of gluconeogenesis GO:0006111 TAS
    retrograde protein transport, ER to cytosol GO:0030970 IDA
    negative regulation of acute inflammatory response to antigenic stimulus GO:0002865 IMP
Subcellular Localization
    low-density lipoprotein particle GO:0034362 IDA
    very-low-density lipoprotein particle GO:0034361 IDA
    cytoplasmic microtubule GO:0005881 IDA
    endoplasmic reticulum GO:0005783 TAS
    plasma membrane GO:0005886 TAS
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
 Experiment description of studies that identified VIMP in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VIMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA4 3308
Affinity Capture-Western Homo sapiens
2 UFD1L 7353
Affinity Capture-Western Homo sapiens
3 VCP 7415
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 SAA1 6288
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 DERL1 79139
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which VIMP is involved
No pathways found





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