Gene description for NPLOC4
Gene name nuclear protein localization 4 homolog (S. cerevisiae)
Gene symbol NPLOC4
Other names/aliases NPL4
Species Homo sapiens
 Database cross references - NPLOC4
ExoCarta ExoCarta_55666
Entrez Gene 55666
HGNC 18261
MIM 606590
UniProt Q8TAT6  
 NPLOC4 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NPLOC4
Molecular Function
    zinc ion binding GO:0008270 IEA
    ubiquitin binding GO:0043130 IBA
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IBA
Biological Process
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    Golgi organization GO:0007030 ISS
    membrane fusion GO:0061025 ISS
    DNA repair GO:0006281 TAS
    error-free translesion synthesis GO:0070987 TAS
    translesion synthesis GO:0019985 TAS
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISS
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
    endoplasmic reticulum GO:0005783 ISS
    protein complex GO:0043234 IPI
    nuclear outer membrane-endoplasmic reticulum membrane network GO:0042175 ISS
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 ISS
    cytosol GO:0005829 IEA
 Experiment description of studies that identified NPLOC4 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NPLOC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UFD1L 7353
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NPLOC4 is involved
PathwayEvidenceSource
Translesion Synthesis by POLH TAS Reactome





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