Gene description for CSN3
Gene name casein kappa
Gene symbol CSN3
Other names/aliases CSN10
CSNK
KCA
Species Homo sapiens
 Database cross references - CSN3
ExoCarta ExoCarta_1448
Vesiclepedia VP_1448
Entrez Gene 1448
HGNC 2446
MIM 601695
UniProt P07498  
 CSN3 identified in sEVs derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for CSN3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    lactation GO:0007595 IBA
    lactation GO:0007595 IDA
    protein stabilization GO:0050821 IBA
    protein stabilization GO:0050821 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CSN3 in sEVs
1
Experiment ID 48
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
HSC70|CD63|CD86|MHCII
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for CSN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBPMS 11030
Two-hybrid Homo sapiens
2 MAPRE1 22919
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
3 UBQLN2 29978
Two-hybrid Homo sapiens
4 RELA 5970
Affinity Capture-Western Homo sapiens
5 MGAT5B  
Two-hybrid Homo sapiens
6 SOCS3 9021
Affinity Capture-Western Homo sapiens
7 ARHGAP36  
Affinity Capture-MS Homo sapiens
8 VENTX  
Two-hybrid Homo sapiens
9 UBQLN1 29979
Two-hybrid Homo sapiens
10 COPS7A 50813
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
11 EIF3E 3646
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 TP53 7157
Negative Genetic Homo sapiens
13 PRNP 5621
Reconstituted Complex Homo sapiens
14 TUBG1 7283
Co-localization Homo sapiens
15 PTPDC1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CSN3 is involved
PathwayEvidenceSource
Miscellaneous transport and binding events TAS Reactome
Transport of small molecules TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here