Gene description for DCAF8
Gene name DDB1 and CUL4 associated factor 8
Gene symbol DCAF8
Other names/aliases GAN2
H326
WDR42A
Species Homo sapiens
 Database cross references - DCAF8
ExoCarta ExoCarta_50717
Vesiclepedia VP_50717
Entrez Gene 50717
HGNC 24891
MIM 615820
UniProt Q5TAQ9  
 DCAF8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DCAF8
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IBA
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IDA
 Experiment description of studies that identified DCAF8 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DCAF8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 Lmna 16905
Affinity Capture-MS Mus musculus
3 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RBPMS 11030
Two-hybrid Homo sapiens
5 KPNA1 3836
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 ARHGEF26 26084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNHIT2 741
Affinity Capture-MS Homo sapiens
8 KPNB1 3837
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 EPB41L5 57669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 BRD2  
Co-fractionation Homo sapiens
12 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 DNAJC15  
Affinity Capture-MS Homo sapiens
15 TRIM54  
Two-hybrid Homo sapiens
16 GSK3A 2931
Two-hybrid Homo sapiens
17 PARK2  
Affinity Capture-MS Homo sapiens
18 DDA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
19 Atm  
Affinity Capture-MS Mus musculus
20 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 COPS6 10980
Affinity Capture-MS Homo sapiens
22 COPS5 10987
Affinity Capture-MS Homo sapiens
23 SUV39H1  
Two-hybrid Homo sapiens
24 Mzt2  
Affinity Capture-MS Mus musculus
25 ZNF460  
Affinity Capture-MS Homo sapiens
26 LOC81691 81691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 STOX2  
Affinity Capture-MS Homo sapiens
28 CALR 811
Co-fractionation Homo sapiens
29 PARP14 54625
Affinity Capture-MS Homo sapiens
30 FASTKD2  
Affinity Capture-MS Homo sapiens
31 CSNK2B 1460
Affinity Capture-MS Homo sapiens
32 DNMT3A 1788
Affinity Capture-Western Homo sapiens
33 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TFB1M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CPA6  
Affinity Capture-MS Homo sapiens
36 STAM2 10254
Co-fractionation Homo sapiens
37 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CUL4B 8450
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 LIPK  
Affinity Capture-MS Homo sapiens
40 Ddb1 13194
Affinity Capture-MS Mus musculus
41 METTL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CCT5 22948
Affinity Capture-MS Homo sapiens
43 BACH1 571
Affinity Capture-MS Homo sapiens
44 DCAF8L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PTPN21 11099
Affinity Capture-MS Homo sapiens
46 AMPD2 271
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RAN 5901
Affinity Capture-MS Homo sapiens
48 C10orf2 56652
Affinity Capture-MS Homo sapiens
49 PDCD1  
Affinity Capture-MS Homo sapiens
50 COPS3 8533
Affinity Capture-Western Homo sapiens
51 SDPR 8436
Co-fractionation Homo sapiens
52 SEC61B 10952
Affinity Capture-MS Homo sapiens
53 GTPBP3  
Two-hybrid Homo sapiens
54 ZRANB1 54764
Affinity Capture-MS Homo sapiens
55 ACTN1 87
Co-fractionation Homo sapiens
56 COPS2 9318
Affinity Capture-Western Homo sapiens
57 COPS7A 50813
Co-fractionation Homo sapiens
58 AMBRA1  
Affinity Capture-MS Homo sapiens
59 XPO1 7514
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 EGLN3  
Affinity Capture-MS Homo sapiens
61 CCT6A 908
Affinity Capture-MS Homo sapiens
62 GGH 8836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SFRP4 6424
Affinity Capture-MS Homo sapiens
64 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 PRMT8  
Two-hybrid Homo sapiens
66 CD9 928
Co-fractionation Homo sapiens
67 THAP1  
Two-hybrid Homo sapiens
68 PRMT5 10419
Co-fractionation Homo sapiens
69 MYC  
Affinity Capture-MS Homo sapiens
70 SLC3A2 6520
Co-fractionation Homo sapiens
71 DNAJC9 23234
Affinity Capture-MS Homo sapiens
72 GSTK1 373156
Affinity Capture-MS Homo sapiens
73 MYO9B 4650
Affinity Capture-MS Homo sapiens
74 PLA2G2D  
Affinity Capture-MS Homo sapiens
75 RAF1 5894
Two-hybrid Homo sapiens
76 CCND1 595
Affinity Capture-MS Homo sapiens
77 MDM2  
Affinity Capture-RNA Homo sapiens
78 FARP1 10160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 HUWE1 10075
Affinity Capture-MS Homo sapiens
80 LYZL2  
Affinity Capture-MS Homo sapiens
81 CDC25A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 DNAJC28  
Affinity Capture-MS Homo sapiens
83 FBXW11  
Affinity Capture-MS Homo sapiens
84 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 WDR77 79084
Co-fractionation Homo sapiens
86 PDE7A  
Affinity Capture-MS Homo sapiens
87 COPS4 51138
Co-fractionation Homo sapiens
88 EZR 7430
Affinity Capture-MS Homo sapiens
89 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
90 DCAF11  
Co-fractionation Homo sapiens
91 NDUFAF7  
Affinity Capture-MS Homo sapiens
92 EPB41L2 2037
Co-fractionation Homo sapiens
93 C1orf106  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CSN1S1 1446
Affinity Capture-MS Homo sapiens
96 C16orf72 29035
Affinity Capture-MS Homo sapiens
97 BRD1 23774
Affinity Capture-MS Homo sapiens
98 DNAJC1 64215
Affinity Capture-MS Homo sapiens
99 PODN 127435
Affinity Capture-MS Homo sapiens
100 PRMT1 3276
Two-hybrid Homo sapiens
101 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DCAF8 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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