Gene description for SDPR
Gene name serum deprivation response
Gene symbol SDPR
Other names/aliases CAVIN2
PS-p68
SDR
cavin-2
Species Homo sapiens
 Database cross references - SDPR
ExoCarta ExoCarta_8436
Vesiclepedia VP_8436
Entrez Gene 8436
HGNC 10690
MIM 606728
UniProt O95810  
 SDPR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SDPR
Molecular Function
    phosphatidylserine binding GO:0001786 IDA
    protein kinase C binding GO:0005080 IBA
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 TAS
Biological Process
    plasma membrane tubulation GO:0097320 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    caveola GO:0005901 IBA
    caveola GO:0005901 IDA
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified SDPR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SDPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAN1  
Affinity Capture-MS Homo sapiens
2 RPL11 6135
Co-fractionation Homo sapiens
3 PLEKHF1 79156
Two-hybrid Homo sapiens
4 PRKCZ 5590
Affinity Capture-MS Homo sapiens
5 MIER1  
Co-fractionation Homo sapiens
6 KPNA3 3839
Co-fractionation Homo sapiens
7 COPS2 9318
Co-fractionation Homo sapiens
8 HADHB 3032
Co-fractionation Homo sapiens
9 MCRS1  
Two-hybrid Homo sapiens
10 DVL2 1856
Affinity Capture-MS Homo sapiens
11 C11orf58  
Co-fractionation Homo sapiens
12 ATL3 25923
Co-fractionation Homo sapiens
13 TRMT10C 54931
Co-fractionation Homo sapiens
14 SRPK2 6733
Co-fractionation Homo sapiens
15 WBP11  
Co-fractionation Homo sapiens
16 PFKP 5214
Co-fractionation Homo sapiens
17 TCOF1 6949
Co-fractionation Homo sapiens
18 THRAP3 9967
Co-fractionation Homo sapiens
19 REEP5 7905
Co-fractionation Homo sapiens
20 BCAP31 10134
Co-fractionation Homo sapiens
21 PLEKHF2 79666
Two-hybrid Homo sapiens
22 NR3C1 2908
Proximity Label-MS Homo sapiens
23 CD9 928
Co-fractionation Homo sapiens
24 MAP1B 4131
Co-fractionation Homo sapiens
25 NUDT18  
Two-hybrid Homo sapiens
26 RTN4 57142
Co-fractionation Homo sapiens
27 RRP15  
Co-fractionation Homo sapiens
28 TRIM54  
Two-hybrid Homo sapiens
29 ACIN1 22985
Co-fractionation Homo sapiens
30 DCAF8 50717
Co-fractionation Homo sapiens
31 C12orf49  
Negative Genetic Homo sapiens
32 MOV10 4343
Co-fractionation Homo sapiens
33 A1CF  
Two-hybrid Homo sapiens
34 EEF1D 1936
Co-fractionation Homo sapiens
35 UBE2O 63893
Affinity Capture-MS Homo sapiens
36 MYO1E 4643
Co-fractionation Homo sapiens
37 KPNB1 3837
Co-fractionation Homo sapiens
38 RPL23A 6147
Co-fractionation Homo sapiens
39 PTTG1IP 754
Co-fractionation Homo sapiens
40 PTRF 284119
Co-fractionation Homo sapiens
41 SSRP1 6749
Co-fractionation Homo sapiens
42 Set 56086
Affinity Capture-MS Mus musculus
43 SDPR 8436
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 H2AFY 9555
Co-fractionation Homo sapiens
45 HIST1H2AJ 8331
Co-fractionation Homo sapiens
46 CC2D1A 54862
Co-fractionation Homo sapiens
47 SLC3A2 6520
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SDPR is involved
No pathways found





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