Gene description for PRKCZ
Gene name protein kinase C, zeta
Gene symbol PRKCZ
Other names/aliases PKC-ZETA
PKC2
Species Homo sapiens
 Database cross references - PRKCZ
ExoCarta ExoCarta_5590
Vesiclepedia VP_5590
Entrez Gene 5590
HGNC 9412
MIM 176982
UniProt Q05513  
 PRKCZ identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PRKCZ
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    diacylglycerol-dependent serine/threonine kinase activity GO:0004697 EXP
    diacylglycerol-dependent serine/threonine kinase activity GO:0004697 TAS
    calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IEA
    diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    potassium channel regulator activity GO:0015459 IEA
    protein kinase binding GO:0019901 IEA
    phospholipase binding GO:0043274 IEA
    insulin receptor substrate binding GO:0043560 IC
    protein-containing complex binding GO:0044877 IEA
    metal ion binding GO:0046872 IEA
    14-3-3 protein binding GO:0071889 IEA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IEA
    positive regulation of cell-matrix adhesion GO:0001954 IEA
    protein phosphorylation GO:0006468 IDA
    inflammatory response GO:0006954 IEA
    signal transduction GO:0007165 TAS
    cell surface receptor signaling pathway GO:0007166 IEA
    long-term memory GO:0007616 IEA
    positive regulation of cell population proliferation GO:0008284 IEA
    cell migration GO:0016477 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    establishment of cell polarity GO:0030010 IBA
    establishment of cell polarity GO:0030010 ISS
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    positive regulation of interleukin-10 production GO:0032733 ISS
    positive regulation of interleukin-13 production GO:0032736 ISS
    positive regulation of interleukin-4 production GO:0032753 ISS
    positive regulation of interleukin-5 production GO:0032754 ISS
    cellular response to insulin stimulus GO:0032869 IBA
    intracellular signal transduction GO:0035556 IBA
    negative regulation of apoptotic process GO:0043066 IEA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 ISS
    positive regulation of T-helper 2 cell differentiation GO:0045630 ISS
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    positive regulation of insulin receptor signaling pathway GO:0046628 ISS
    vesicle transport along microtubule GO:0047496 IEA
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    positive regulation of protein transport GO:0051222 IEA
    membrane depolarization GO:0051899 IEA
    membrane hyperpolarization GO:0060081 IEA
    long-term synaptic potentiation GO:0060291 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    protein kinase C signaling GO:0070528 IEA
    protein localization to plasma membrane GO:0072659 IBA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IEA
    neuron projection extension GO:1990138 IEA
    positive regulation of excitatory postsynaptic potential GO:2000463 ISS
    positive regulation of T-helper 2 cell cytokine production GO:2000553 ISS
Subcellular Localization
    stress fiber GO:0001725 IEA
    nuclear envelope GO:0005635 IEA
    cytoplasm GO:0005737 TAS
    endosome GO:0005768 IEA
    microtubule organizing center GO:0005815 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IDA
    bicellular tight junction GO:0005923 IEA
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 IEA
    nuclear matrix GO:0016363 IEA
    cell junction GO:0030054 TAS
    cell leading edge GO:0031252 IEA
    vesicle GO:0031982 IDA
    myelin sheath abaxonal region GO:0035748 IEA
    axon hillock GO:0043203 IEA
    apical cortex GO:0045179 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    extracellular exosome GO:0070062 HDA
    tight junction GO:0070160 NAS
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    glutamatergic synapse GO:0098978 IEA
    PAR polarity complex GO:0120157 ISS
 Experiment description of studies that identified PRKCZ in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PRKCZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 F11R 50848
Co-localization Homo sapiens
3 CLTC 1213
Affinity Capture-MS Homo sapiens
4 MRPL48  
Affinity Capture-MS Homo sapiens
5 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 EEF1G 1937
Affinity Capture-MS Homo sapiens
7 MSH6 2956
Affinity Capture-Western Homo sapiens
8 MARCKS 4082
Biochemical Activity Homo sapiens
9 PAWR 5074
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 PPIL4  
Affinity Capture-MS Homo sapiens
11 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
12 MRPL45 84311
Affinity Capture-MS Homo sapiens
13 LGALS1 3956
Affinity Capture-MS Homo sapiens
14 MRPL37 51253
Affinity Capture-MS Homo sapiens
15 TAB1 10454
Affinity Capture-MS Homo sapiens
16 AKT3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
17 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
18 MRPL50 54534
Affinity Capture-MS Homo sapiens
19 VHL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 MRPL52  
Affinity Capture-MS Homo sapiens
21 MRPL49 740
Affinity Capture-MS Homo sapiens
22 RIPK1 8737
Affinity Capture-Western Homo sapiens
23 WDR26 80232
Affinity Capture-MS Homo sapiens
24 NCF1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
25 DENND5A 23258
Two-hybrid Homo sapiens
26 MRPL12 6182
Affinity Capture-MS Homo sapiens
27 PPP1CC 5501
Affinity Capture-MS Homo sapiens
28 TRIM41 90933
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RNH1 6050
Affinity Capture-MS Homo sapiens
30 MAP2K5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 PSMC5 5705
Affinity Capture-MS Homo sapiens
32 PPIA 5478
Affinity Capture-MS Homo sapiens
33 MAP1LC3B 81631
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
34 CHCHD2  
Affinity Capture-MS Homo sapiens
35 EIF3B 8662
Affinity Capture-MS Homo sapiens
36 FLNA 2316
Affinity Capture-MS Homo sapiens
37 KCTD5 54442
Affinity Capture-MS Homo sapiens
38 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 NPM1 4869
Affinity Capture-MS Homo sapiens
40 YWHAG 7532
Affinity Capture-Western Homo sapiens
41 RPS12 6206
Affinity Capture-MS Homo sapiens
42 C1qbp 12261
Two-hybrid Mus musculus
43 TIAM1  
Biochemical Activity Homo sapiens
44 EIF3E 3646
Affinity Capture-MS Homo sapiens
45 DYNLL1 8655
Affinity Capture-MS Homo sapiens
46 MBP 4155
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
47 GRWD1 83743
Affinity Capture-MS Homo sapiens
48 MRPL39 54148
Affinity Capture-MS Homo sapiens
49 PTPN14 5784
Affinity Capture-MS Homo sapiens
50 YWHAH 7533
Affinity Capture-Western Homo sapiens
51 CCDC115 84317
Two-hybrid Homo sapiens
52 PRDX4 10549
Affinity Capture-MS Homo sapiens
53 CSNK2B 1460
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
54 GAPDH 2597
Affinity Capture-MS Homo sapiens
55 EEF1A1 1915
Affinity Capture-MS Homo sapiens
56 SLC25A3 5250
Affinity Capture-MS Homo sapiens
57 GSK3B 2932
Co-localization Homo sapiens
58 APPL1 26060
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
59 YWHAB 7529
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
60 CCT2 10576
Affinity Capture-MS Homo sapiens
61 NCOA3  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
62 ADAP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
63 Sqstm1  
Affinity Capture-Western Rattus norvegicus
64 LLGL1 3996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 UTP14A 10813
Two-hybrid Homo sapiens
66 TPR 7175
Affinity Capture-MS Homo sapiens
67 MRPL54  
Affinity Capture-MS Homo sapiens
68 IRAK1  
Affinity Capture-Western Homo sapiens
69 MAP1B 4131
Affinity Capture-MS Homo sapiens
70 PIAS4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
71 ARMC8 25852
Affinity Capture-MS Homo sapiens
72 BEGAIN  
Affinity Capture-MS Homo sapiens
73 CCT5 22948
Affinity Capture-MS Homo sapiens
74 COPB1 1315
Affinity Capture-MS Homo sapiens
75 RNF146  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
76 RPS6KB1 6198
Affinity Capture-Western Homo sapiens
77 GID8 54994
Affinity Capture-MS Homo sapiens
78 TUBA1C 84790
Affinity Capture-MS Homo sapiens
79 RPA2 6118
Co-fractionation Homo sapiens
80 VCP 7415
Affinity Capture-MS Homo sapiens
81 TRIM21 6737
Affinity Capture-MS Homo sapiens
82 PPP2CA 5515
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
83 NCL 4691
Biochemical Activity Homo sapiens
84 NSRP1  
Affinity Capture-MS Homo sapiens
85 KIF11 3832
Affinity Capture-MS Homo sapiens
86 YWHAQ 10971
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
87 NMT2 9397
Two-hybrid Homo sapiens
88 RPLP1 6176
Affinity Capture-MS Homo sapiens
89 SNRPD1 6632
Affinity Capture-MS Homo sapiens
90 TFF1 7031
Phenotypic Enhancement Homo sapiens
91 SDPR 8436
Affinity Capture-MS Homo sapiens
92 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
93 FEZ2 9637
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 KCTD2  
Affinity Capture-MS Homo sapiens
95 SLC25A5 292
Affinity Capture-MS Homo sapiens
96 GABARAP 11337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
97 PARD3 56288
Affinity Capture-Western Homo sapiens
98 IMMT 10989
Affinity Capture-MS Homo sapiens
99 HSPA5 3309
Affinity Capture-MS Homo sapiens
100 HSPA9 3313
Affinity Capture-MS Homo sapiens
101 KPNA1 3836
Affinity Capture-Western Homo sapiens
102 GRM5  
Co-localization Homo sapiens
103 MSH2 4436
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
104 TMEM160 54958
Affinity Capture-MS Homo sapiens
105 BAG2 9532
Affinity Capture-MS Homo sapiens
106 ECT2 1894
Affinity Capture-Western Homo sapiens
107 CCT6A 908
Affinity Capture-MS Homo sapiens
108 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
109 NPM3 10360
Affinity Capture-MS Homo sapiens
110 PRKCZ 5590
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
111 TRAF6 7189
Affinity Capture-Western Homo sapiens
112 YWHAZ 7534
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
113 MYCBP 26292
Affinity Capture-MS Homo sapiens
114 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
115 NAP1L1 4673
Affinity Capture-MS Homo sapiens
116 EEF1B2 1933
Affinity Capture-MS Homo sapiens
117 PDPK1 5170
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
118 KBTBD7  
Affinity Capture-MS Homo sapiens
119 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
120 PRKCI 5584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 TUBA4A 7277
Affinity Capture-MS Homo sapiens
122 MRPL19 9801
Affinity Capture-MS Homo sapiens
123 JAK1 3716
Affinity Capture-MS Homo sapiens
124 EIF4A1 1973
Affinity Capture-MS Homo sapiens
125 WWC1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 MRPL46  
Affinity Capture-MS Homo sapiens
127 CFL1 1072
Affinity Capture-MS Homo sapiens
128 MRPL1  
Affinity Capture-MS Homo sapiens
129 AKT2 208
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
130 HIST1H1A 3024
Biochemical Activity Homo sapiens
131 GRB14 2888
Affinity Capture-Western Homo sapiens
132 RAF1 5894
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
133 INPP5B 3633
Co-fractionation Homo sapiens
134 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
135 MRPL38  
Affinity Capture-MS Homo sapiens
136 TLR4  
Affinity Capture-Western Homo sapiens
137 NFATC2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
138 MRPL18 29074
Affinity Capture-MS Homo sapiens
139 SNRPD2 6633
Affinity Capture-MS Homo sapiens
140 EIF3H 8667
Affinity Capture-MS Homo sapiens
141 DNAJC13 23317
Affinity Capture-MS Homo sapiens
142 GBAS 2631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 STUB1 10273
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
144 GSN 2934
Affinity Capture-MS Homo sapiens
145 RELA 5970
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
146 FEZ1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
147 LLGL2 3993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 FADD 8772
Affinity Capture-Western Homo sapiens
149 IGHV4-31 28396
Affinity Capture-MS Homo sapiens
150 PSMD1 5707
Affinity Capture-MS Homo sapiens
151 MAPT  
Biochemical Activity Homo sapiens
152 PARD6G 84552
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 STK38 11329
Affinity Capture-MS Homo sapiens
154 DDX3X 1654
Affinity Capture-MS Homo sapiens
155 ZNF71  
Two-hybrid Homo sapiens
156 KRT10 3858
Affinity Capture-Western Homo sapiens
157 MRPL53  
Affinity Capture-MS Homo sapiens
158 KEAP1 9817
Affinity Capture-MS Homo sapiens
159 CDC37 11140
Affinity Capture-MS Homo sapiens
160 AJUBA  
Affinity Capture-Western Homo sapiens
161 Pard6b  
Affinity Capture-MS Mus musculus
162 TUBB3 10381
Affinity Capture-MS Homo sapiens
163 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
164 ABL1 25
Affinity Capture-Western Homo sapiens
165 HSPB1 3315
Affinity Capture-MS Homo sapiens
166 CREBBP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
167 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
168 TUBB4A 10382
Affinity Capture-MS Homo sapiens
169 TUBB6 84617
Affinity Capture-MS Homo sapiens
170 ESR1  
Affinity Capture-Western Homo sapiens
171 TLR9  
Affinity Capture-Western Homo sapiens
172 PPP1R14A 94274
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
173 MAPK7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
174 API5 8539
Affinity Capture-MS Homo sapiens
175 PARD6B 84612
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 LRRK2 120892
Biochemical Activity Homo sapiens
177 EEF1D 1936
Affinity Capture-MS Homo sapiens
178 DAPK3 1613
Reconstituted Complex Homo sapiens
179 BLVRA 644
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
180 PRDX1 5052
Affinity Capture-MS Homo sapiens
181 FLNC 2318
Affinity Capture-MS Homo sapiens
182 C1QBP 708
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 KCTD17 79734
Affinity Capture-MS Homo sapiens
184 EIF5A 1984
Affinity Capture-MS Homo sapiens
185 CD44 960
Affinity Capture-Western Homo sapiens
186 MRPL55  
Affinity Capture-MS Homo sapiens
187 ANXA2 302
Affinity Capture-MS Homo sapiens
188 CKAP4 10970
Affinity Capture-MS Homo sapiens
189 PTRF 284119
Affinity Capture-MS Homo sapiens
190 PSMC4 5704
Affinity Capture-MS Homo sapiens
191 PARD6A