Gene description for INPP5B
Gene name inositol polyphosphate-5-phosphatase, 75kDa
Gene symbol INPP5B
Other names/aliases 5PTase
Species Homo sapiens
 Database cross references - INPP5B
ExoCarta ExoCarta_3633
Entrez Gene 3633
HGNC 6077
MIM 147264
UniProt P32019  
 INPP5B identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for INPP5B
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IDA
    inositol-1,4,5-trisphosphate 5-phosphatase activity GO:0052658 IDA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    spermatogenesis GO:0007283 IEA
    inositol phosphate metabolic process GO:0043647 TAS
    phosphatidylinositol dephosphorylation GO:0046856 IDA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    sperm motility GO:0030317 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    regulation of protein processing GO:0070613 IEA
    in utero embryonic development GO:0001701 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    phagocytic vesicle membrane GO:0030670 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    Golgi apparatus GO:0005794 IEA
    early endosome membrane GO:0031901 IEA
 Experiment description of studies that identified INPP5B in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INPP5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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