Gene description for KCTD5
Gene name potassium channel tetramerization domain containing 5
Gene symbol KCTD5
Other names/aliases -
Species Homo sapiens
 Database cross references - KCTD5
ExoCarta ExoCarta_54442
Vesiclepedia VP_54442
Entrez Gene 54442
HGNC 21423
MIM 611285
UniProt Q9NXV2  
 KCTD5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KCTD5
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein-containing complex binding GO:0044877 IDA
    cullin family protein binding GO:0097602 IBA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
 Experiment description of studies that identified KCTD5 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KCTD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 EFNA1  
Affinity Capture-MS Homo sapiens
3 GRK5 2869
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 PRKCZ 5590
Affinity Capture-MS Homo sapiens
6 GAN 8139
Affinity Capture-MS Homo sapiens
7 GNG2 54331
Affinity Capture-MS Homo sapiens
8 FASN 2194
Negative Genetic Homo sapiens
9 C21orf2  
Affinity Capture-MS Homo sapiens
10 RC3H1 149041
Affinity Capture-MS Homo sapiens
11 FAS 355
Proximity Label-MS Homo sapiens
12 CUL2 8453
Affinity Capture-MS Homo sapiens
13 PRKAB2 5565
Two-hybrid Homo sapiens
14 MCM7 4176
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 NEK6 10783
Two-hybrid Homo sapiens
17 RC3H2  
Affinity Capture-MS Homo sapiens
18 GIT2 9815
Two-hybrid Homo sapiens
19 TRIP6 7205
Affinity Capture-MS Homo sapiens
20 SRSF1 6426
Affinity Capture-MS Homo sapiens
21 POLK  
Affinity Capture-MS Homo sapiens
22 DGCR8  
Affinity Capture-MS Homo sapiens
23 CD1A 909
Two-hybrid Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 SMURF1 57154
Affinity Capture-MS Homo sapiens
26 ARRDC1 92714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 KCND2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RPUSD4 84881
Affinity Capture-MS Homo sapiens
29 TMEM45A  
Affinity Capture-MS Homo sapiens
30 GJA1 2697
Affinity Capture-MS Homo sapiens
31 DDX58 23586
Affinity Capture-RNA Homo sapiens
32 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
33 NXF1 10482
Two-hybrid Homo sapiens
34 ESR1  
Affinity Capture-MS Homo sapiens
35 CNRIP1 25927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 UFL1 23376
Affinity Capture-MS Homo sapiens
37 EFNA3  
Affinity Capture-MS Homo sapiens
38 RPL18A 6142
Affinity Capture-MS Homo sapiens
39 ZNF711  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
40 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
41 SREBF2 6721
Positive Genetic Homo sapiens
42 B3GNT2 10678
Affinity Capture-MS Homo sapiens
43 ZNF692  
Affinity Capture-MS Homo sapiens
44 RPL7A 6130
Affinity Capture-MS Homo sapiens
45 EFNA4  
Affinity Capture-MS Homo sapiens
46 SLC9A3R1 9368
Affinity Capture-MS Homo sapiens
47 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SNX27 81609
Affinity Capture-MS Homo sapiens
49 DDRGK1 65992
Affinity Capture-MS Homo sapiens
50 Kctd5  
Affinity Capture-MS Mus musculus
51 NPM1 4869
Affinity Capture-MS Homo sapiens
52 FAM193B 54540
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
53 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PRDX2 7001
Affinity Capture-MS Homo sapiens
55 KCTD5 54442
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
56 REPIN1  
Affinity Capture-MS Homo sapiens
57 GORASP2 26003
Affinity Capture-Western Homo sapiens
58 CYLD  
Affinity Capture-MS Homo sapiens
59 EP300 2033
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which KCTD5 is involved
No pathways found





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