Gene description for TRIP6
Gene name thyroid hormone receptor interactor 6
Gene symbol TRIP6
Other names/aliases OIP-1
OIP1
TRIP-6
TRIP6i2
ZRP-1
Species Homo sapiens
 Database cross references - TRIP6
ExoCarta ExoCarta_7205
Entrez Gene 7205
HGNC 12311
MIM 602933
UniProt Q15654  
 TRIP6 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TRIP6
Molecular Function
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    interleukin-1 receptor binding GO:0005149 IDA
    kinase binding GO:0019900 IPI
    thyroid hormone receptor binding GO:0046966 NAS
Biological Process
    positive regulation of cell migration GO:0030335 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    focal adhesion assembly GO:0048041 NAS
    transcription, DNA-templated GO:0006351 IEA
    release of cytoplasmic sequestered NF-kappaB GO:0008588 IDA
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IDA
    interleukin-1 receptor complex GO:0045323 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IEA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified TRIP6 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RERE 473
Two-hybrid Homo sapiens
2 VCL 7414
Two-hybrid Homo sapiens
3 STOM 2040
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRIP6 is involved
No pathways found





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