Gene description for AFAP1L1
Gene name actin filament associated protein 1-like 1
Gene symbol AFAP1L1
Other names/aliases -
Species Homo sapiens
 Database cross references - AFAP1L1
ExoCarta ExoCarta_134265
Entrez Gene 134265
HGNC 26714
MIM 614410
UniProt Q8TED9  
 AFAP1L1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AFAP1L1
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    podosome GO:0002102 IEA
    invadopodium GO:0071437 IEA
    cytoplasm GO:0005737 IDA
    cell junction GO:0030054 IEA
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified AFAP1L1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AFAP1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP6  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AFAP1L1 is involved
No pathways found





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