Gene description for MYPN
Gene name myopalladin
Gene symbol MYPN
Other names/aliases CMD1DD
CMH22
MYOP
RCM4
Species Homo sapiens
 Database cross references - MYPN
ExoCarta ExoCarta_84665
Entrez Gene 84665
HGNC 23246
MIM 608517
UniProt Q86TC9  
 MYPN identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MYPN
Molecular Function
    muscle alpha-actinin binding GO:0051371 IPI
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IPI
    actin binding GO:0003779 IEA
    SH3 domain binding GO:0017124 IPI
Biological Process
    sarcomere organization GO:0045214 IMP
Subcellular Localization
    Z disc GO:0030018 IDA
    nucleus GO:0005634 ISS
    I band GO:0031674 IDA
 Experiment description of studies that identified MYPN in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MYPN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTN2 88
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 NEBL 10529
Two-hybrid Homo sapiens
3 ANKRD1 27063
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 ANKRD23 200539
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 NEB 4703
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 TTN 7273
Two-hybrid Homo sapiens
7 ACTN3 89
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MYPN is involved
No pathways found





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