Gene description for PTPN6
Gene name	protein tyrosine phosphatase, non-receptor type 6
Gene symbol	PTPN6
Other names/aliases	HCP HCPH HPTP1C PTP-1C SH-PTP1 SHP-1 SHP-1L SHP1
Species	Homo sapiens
Database cross references - PTPN6
ExoCarta	ExoCarta_5777
Entrez Gene	5777
HGNC	9658
MIM	176883
UniProt	P29350
PTPN6 identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026
Urine	19056867

Gene ontology annotations for PTPN6

Molecular Function     SH3 domain binding GO:0017124 IEA     SH2 domain binding GO:0042169 IEA     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 IDA     protein kinase binding GO:0019901 IPI     phosphotyrosine binding GO:0001784 IEA     protein tyrosine phosphatase activity GO:0004725 TAS     protein binding GO:0005515 IPI Biological Process     abortive mitotic cell cycle GO:0033277 IEA     cytokine-mediated signaling pathway GO:0019221 TAS     blood coagulation GO:0007596 TAS     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     negative regulation of MAP kinase activity GO:0043407 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     apoptotic process GO:0006915 TAS     negative regulation of T cell receptor signaling pathway GO:0050860 IEA     positive regulation of cell proliferation GO:0008284 IMP     negative regulation of B cell receptor signaling pathway GO:0050859 IEA     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 IEA     peptidyl-tyrosine dephosphorylation GO:0035335 TAS     cell differentiation GO:0030154 IDA     regulation of B cell differentiation GO:0045577 IEA     megakaryocyte development GO:0035855 IEA     platelet aggregation GO:0070527 IEA     leukocyte migration GO:0050900 TAS     T cell costimulation GO:0031295 TAS     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     positive regulation of cell adhesion mediated by integrin GO:0033630 IEA     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     negative regulation of T cell proliferation GO:0042130 IEA     G-protein coupled receptor signaling pathway GO:0007186 TAS     regulation of ERK1 and ERK2 cascade GO:0070372 IDA     interferon-gamma-mediated signaling pathway GO:0060333 TAS     regulation of G1/S transition of mitotic cell cycle GO:2000045 IMP     negative regulation of cell proliferation GO:0008285 NAS     regulation of type I interferon-mediated signaling pathway GO:0060338 TAS     type I interferon signaling pathway GO:0060337 TAS     B cell receptor signaling pathway GO:0050853 IEA     cell proliferation GO:0008283 IDA     protein dephosphorylation GO:0006470 IDA     platelet formation GO:0030220 IEA     natural killer cell mediated cytotoxicity GO:0042267 IEA Subcellular Localization     cytoplasm GO:0005737 IDA     nucleolus GO:0005730 IDA     cytosol GO:0005829 TAS     membrane GO:0016020 TAS     extracellular exosome GO:0070062 IDA     alpha-beta T cell receptor complex GO:0042105 IEA     nucleus GO:0005634 IDA     cell-cell junction GO:0005911 IEA