Gene description for BRIX1
Gene name BRX1, biogenesis of ribosomes
Gene symbol BRIX1
Other names/aliases BRIX
BXDC2
Species Homo sapiens
 Database cross references - BRIX1
ExoCarta ExoCarta_55299
Entrez Gene 55299
HGNC 24170
UniProt Q8TDN6  
 BRIX1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BRIX1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    ribosomal large subunit assembly GO:0000027 IBA
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified BRIX1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BRIX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF9  
Affinity Capture-MS Homo sapiens
2 LYAR 55646
Affinity Capture-MS Homo sapiens
3 UBA2 10054
Two-hybrid Homo sapiens
4 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
5 UNC119  
Two-hybrid Homo sapiens
6 CD48 962
Two-hybrid Homo sapiens
7 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BRIX1 is involved
No pathways found





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