Gene description for CD5
Gene name CD5 molecule
Gene symbol CD5
Other names/aliases LEU1
Species Homo sapiens
 Database cross references - CD5
ExoCarta ExoCarta_921
Entrez Gene 921
HGNC 1685
MIM 153340
UniProt P06127  
 CD5 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD5
Molecular Function
    transmembrane signaling receptor activity GO:0004888 NAS
    receptor activity GO:0004872 NAS
    protein binding GO:0005515 IPI
    scavenger receptor activity GO:0005044 IEA
Biological Process
    T cell costimulation GO:0031295 IEA
    cell recognition GO:0008037 NAS
    cell proliferation GO:0008283 NAS
    apoptotic signaling pathway GO:0097190 IEA
    receptor-mediated endocytosis GO:0006898 IEA
Subcellular Localization
    external side of plasma membrane GO:0009897 IEA
    integral component of plasma membrane GO:0005887 NAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified CD5 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD2 914
Affinity Capture-Western Homo sapiens
2 RASA1 5921
Invitro Homo sapiens
3 CD247 919
Invivo Homo sapiens
Invitro Homo sapiens
4 CD4 920
Invitro Homo sapiens
5 CAMK2D 817
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 PIK3R1 5295
Invivo Homo sapiens
7 CD6 923
FRET Homo sapiens
Reconstituted Complex Homo sapiens
9 CBL 867
Invitro Homo sapiens
10 TCTE1L  
Two-hybrid Homo sapiens
11 PTPN6 5777
Invivo Homo sapiens
12 ZAP70 7535
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CD5 is involved
No pathways found

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