Gene description for KIF5C
Gene name kinesin family member 5C
Gene symbol KIF5C
Other names/aliases CDCBM2
Species Homo sapiens
 Database cross references - KIF5C
ExoCarta ExoCarta_3800
Entrez Gene 3800
HGNC 6325
MIM 604593
UniProt O60282  
 KIF5C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KIF5C
Molecular Function
    microtubule binding GO:0008017 IEA
    microtubule motor activity GO:0003777 TAS
    protein binding GO:0005515 IPI
    ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 IBA
    ATP binding GO:0005524 IEA
Biological Process
    microtubule-based movement GO:0007018 IBA
    organelle organization GO:0006996 TAS
    cytoskeleton-dependent intracellular transport GO:0030705 IBA
    axon guidance GO:0007411 IBA
    mRNA transport GO:0051028 ISS
    metabolic process GO:0008152 TAS
    protein localization GO:0008104 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    kinesin complex GO:0005871 IEA
    microtubule GO:0005874 IEA
 Experiment description of studies that identified KIF5C in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KIF5C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAQ 10971
Affinity Capture-MS Homo sapiens
2 YWHAG 7532
Affinity Capture-MS Homo sapiens
3 KLC2 64837
Affinity Capture-Western Homo sapiens
4 KLC1 3831
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
6 KIF5B 3799
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which KIF5C is involved
Insulin processing TAS Reactome

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