Gene description for COG6
Gene name component of oligomeric golgi complex 6
Gene symbol COG6
Other names/aliases CDG2L
COD2
SHNS
Species Homo sapiens
 Database cross references - COG6
ExoCarta ExoCarta_57511
Vesiclepedia VP_57511
Entrez Gene 57511
HGNC 18621
MIM 606977
UniProt Q9Y2V7  
 COG6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for COG6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde transport, vesicle recycling within Golgi GO:0000301 IMP
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    Golgi organization GO:0007030 IMP
    protein transport GO:0015031 IEA
    glycosylation GO:0070085 IMP
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    Golgi transport complex GO:0017119 IBA
    Golgi transport complex GO:0017119 IDA
    Golgi transport complex GO:0017119 NAS
    trans-Golgi network membrane GO:0032588 TAS
 Experiment description of studies that identified COG6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLC2 64837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 QARS 5859
Two-hybrid Homo sapiens
3 CD68 968
Affinity Capture-MS Homo sapiens
4 RABEP2 79874
Affinity Capture-MS Homo sapiens
5 CMTM8  
Affinity Capture-MS Homo sapiens
6 SCNM1  
Two-hybrid Homo sapiens
7 UFSP1  
Two-hybrid Homo sapiens
8 NUP62 23636
Affinity Capture-MS Homo sapiens
9 NAV1 89796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DTNA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FPR1  
Affinity Capture-MS Homo sapiens
12 GAS8  
Two-hybrid Homo sapiens
13 POM121  
Two-hybrid Homo sapiens
14 COG2 22796
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 VPS54  
Affinity Capture-MS Homo sapiens
16 AMOTL1 154810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 C9orf78 51759
Affinity Capture-MS Homo sapiens
18 SYCP2L  
Two-hybrid Homo sapiens
19 KLC1 3831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 BCL10  
Two-hybrid Homo sapiens
22 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 WHAMMP3  
Affinity Capture-MS Homo sapiens
24 TSNAX 7257
Two-hybrid Homo sapiens
25 KIF5B 3799
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PPP1R18 170954
Two-hybrid Homo sapiens
27 CSRP2 1466
Two-hybrid Homo sapiens
28 CCDC53 51019
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
29 POC1B 282809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ABI1 10006
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CENPQ  
Affinity Capture-MS Homo sapiens
32 ITFG3 83986
Affinity Capture-MS Homo sapiens
33 IGFN1  
Two-hybrid Homo sapiens
34 RAB6B 51560
Two-hybrid Homo sapiens
35 PSMA1 5682
Two-hybrid Homo sapiens
36 MGC50722  
Two-hybrid Homo sapiens
37 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 STX12 23673
Affinity Capture-MS Homo sapiens
39 GPR17 2840
Affinity Capture-MS Homo sapiens
40 CCDC114  
Affinity Capture-MS Homo sapiens
41 PROKR1  
Affinity Capture-MS Homo sapiens
42 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SPAG5 10615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 VSIG1  
Affinity Capture-MS Homo sapiens
45 CCDC116  
Two-hybrid Homo sapiens
46 RAB3IL1 5866
Two-hybrid Homo sapiens
47 GCGR  
Affinity Capture-MS Homo sapiens
48 ZBTB16  
Two-hybrid Homo sapiens
49 FAM110A  
Two-hybrid Homo sapiens
50 KLC4 89953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ILVBL 10994
Affinity Capture-MS Homo sapiens
52 PSMD14 10213
Affinity Capture-MS Homo sapiens
53 BAIAP2 10458
Two-hybrid Homo sapiens
54 POC1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CNNM3 26505
Two-hybrid Homo sapiens
56 COMTD1 118881
Affinity Capture-MS Homo sapiens
57 NCKAP1 10787
Affinity Capture-MS Homo sapiens
58 KIF5A 3798
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TSGA10  
Two-hybrid Homo sapiens
60 WDYHV1  
Two-hybrid Homo sapiens
61 DTNB 1838
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
62 PKN1 5585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 COG3 83548
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ZFC3H1 196441
Two-hybrid Homo sapiens
66 COG5 10466
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 COG4 25839
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CCDC120  
Two-hybrid Homo sapiens
69 PTAR1 375743
Synthetic Lethality Homo sapiens
70 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 SNAPIN 23557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CD40 958
Affinity Capture-MS Homo sapiens
73 NUP88 4927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RNF40 9810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CYB5B 80777
Affinity Capture-MS Homo sapiens
76 EFNA4  
Affinity Capture-MS Homo sapiens
77 DOCK8 81704
Two-hybrid Homo sapiens
78 NUP62CL  
Affinity Capture-MS Homo sapiens
79 GEM  
Two-hybrid Homo sapiens
80 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 SNRPB 6628
Two-hybrid Homo sapiens
82 NPTN 27020
Affinity Capture-MS Homo sapiens
83 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TRAF6 7189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 EGFR 1956
Affinity Capture-MS Homo sapiens
88 FAM90A1  
Two-hybrid Homo sapiens
89 DUSP16  
Affinity Capture-MS Homo sapiens
90 SASS6 163786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 OCIAD1 54940
Affinity Capture-MS Homo sapiens
92 COG1 9382
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 PLEKHA2 59339
Two-hybrid Homo sapiens
94 SYT17  
Two-hybrid Homo sapiens
95 MFAP1  
Two-hybrid Homo sapiens
96 BICD2 23299
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 COG8 84342
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 PKD2 5311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PPP1R32  
Two-hybrid Homo sapiens
101 ATP7A 538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 ZNF417  
Two-hybrid Homo sapiens
103 C9orf16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PARP16 54956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 SNAI1  
Two-hybrid Homo sapiens
106 NUPL1 9818
Two-hybrid Homo sapiens
107 EXOC5 10640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 RTP5  
Two-hybrid Homo sapiens
112 TSHZ3  
Two-hybrid Homo sapiens
113 HAUS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 C10orf76  
Synthetic Lethality Homo sapiens
115 NEK6 10783
Two-hybrid Homo sapiens
116 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 ATXN7  
Two-hybrid Homo sapiens
118 CCHCR1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
119 CUL5 8065
Two-hybrid Homo sapiens
120 LMO4  
Two-hybrid Homo sapiens
121 CENPF 1063
Affinity Capture-MS Homo sapiens
122 RNF20 56254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 TRAPPC13 80006
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 KIF5C 3800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 BRK1 55845
Affinity Capture-MS Homo sapiens
127 BSG 682
Affinity Capture-MS Homo sapiens
128 C20orf195  
Two-hybrid Homo sapiens
129 RAB7A 7879
Proximity Label-MS Homo sapiens
130 KANK2 25959
Two-hybrid Homo sapiens
131 TMSB4X 7114
Two-hybrid Homo sapiens
132 SNTB2 6645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 COG7 91949
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
134 ARSF 416
Affinity Capture-MS Homo sapiens
135 TTC7B 145567
Two-hybrid Homo sapiens
View the network image/svg+xml



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