Gene description for COG1
Gene name component of oligomeric golgi complex 1
Gene symbol COG1
Other names/aliases CDG2G
LDLB
Species Homo sapiens
 Database cross references - COG1
ExoCarta ExoCarta_9382
Vesiclepedia VP_9382
Entrez Gene 9382
HGNC 6545
MIM 606973
UniProt Q8WTW3  
 COG1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for COG1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde transport, vesicle recycling within Golgi GO:0000301 IMP
    intra-Golgi vesicle-mediated transport GO:0006891 NAS
    Golgi organization GO:0007030 IMP
    Golgi organization GO:0007030 NAS
    protein transport GO:0015031 IEA
    glycosylation GO:0070085 IMP
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi transport complex GO:0017119 IDA
    Golgi transport complex GO:0017119 NAS
    trans-Golgi network membrane GO:0032588 TAS
 Experiment description of studies that identified COG1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFNGR2  
Affinity Capture-MS Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 Rab5c 19345
Affinity Capture-MS Mus musculus
4 NTRK1 4914
Affinity Capture-MS Homo sapiens
5 Sgol2  
Affinity Capture-MS Mus musculus
6 OCIAD1 54940
Affinity Capture-MS Homo sapiens
7 CYB5B 80777
Affinity Capture-MS Homo sapiens
8 EFNA4  
Affinity Capture-MS Homo sapiens
9 Bap1  
Affinity Capture-MS Mus musculus
10 COMTD1 118881
Affinity Capture-MS Homo sapiens
11 GPR17 2840
Affinity Capture-MS Homo sapiens
12 CCDC114  
Affinity Capture-MS Homo sapiens
13 FPR1  
Affinity Capture-MS Homo sapiens
14 GJA1 2697
Proximity Label-MS Homo sapiens
15 NUP155 9631
Proximity Label-MS Homo sapiens
16 LPAR6  
Affinity Capture-MS Homo sapiens
17 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NPTN 27020
Affinity Capture-MS Homo sapiens
19 THOC2 57187
Affinity Capture-MS Homo sapiens
20 GPR182  
Affinity Capture-MS Homo sapiens
21 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 LCK 3932
Proximity Label-MS Homo sapiens
23 CHRM4  
Affinity Capture-MS Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 GCGR  
Affinity Capture-MS Homo sapiens
26 CD40 958
Affinity Capture-MS Homo sapiens
27 MTNR1A  
Two-hybrid Homo sapiens
28 EGFR 1956
Affinity Capture-MS Homo sapiens
29 COG2 22796
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
30 PFN1 5216
Proximity Label-MS Homo sapiens
31 MFSD4  
Affinity Capture-MS Homo sapiens
32 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
33 GORASP1 64689
Proximity Label-MS Homo sapiens
34 UBE2I 7329
Biochemical Activity Homo sapiens
35 GOLGA2 2801
Proximity Label-MS Homo sapiens
36 ITGB3BP  
Affinity Capture-MS Homo sapiens
37 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 GYPB  
Affinity Capture-MS Homo sapiens
39 SLC18A2  
Affinity Capture-MS Homo sapiens
40 COG6 57511
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
41 GPR84  
Affinity Capture-MS Homo sapiens
42 VIPR2  
Affinity Capture-MS Homo sapiens
43 C3orf18  
Affinity Capture-MS Homo sapiens
44 RPA3 6119
Proximity Label-MS Homo sapiens
45 COG8 84342
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
46 GPR45  
Affinity Capture-MS Homo sapiens
47 GOLGA1  
Proximity Label-MS Homo sapiens
48 BIN3 55909
Affinity Capture-MS Homo sapiens
49 WIPI1 55062
Affinity Capture-MS Homo sapiens
50 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SERBP1 26135
Affinity Capture-MS Homo sapiens
52 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 COG3 83548
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
54 EBAG9 9166
Proximity Label-MS Homo sapiens
55 CMTM8  
Affinity Capture-MS Homo sapiens
56 CAPN1 823
Affinity Capture-MS Homo sapiens
57 COG5 10466
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
58 COG7 91949
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
59 ELOVL5 60481
Proximity Label-MS Homo sapiens
60 COG4 25839
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
61 PARP16 54956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SLC2A9  
Affinity Capture-MS Homo sapiens
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