Gene description for COG7
Gene name component of oligomeric golgi complex 7
Gene symbol COG7
Other names/aliases CDG2E
Species Homo sapiens
 Database cross references - COG7
ExoCarta ExoCarta_91949
Vesiclepedia VP_91949
Entrez Gene 91949
HGNC 18622
MIM 606978
UniProt P83436  
 COG7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for COG7
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde transport, vesicle recycling within Golgi GO:0000301 IMP
    protein glycosylation GO:0006486 IMP
    intracellular protein transport GO:0006886 IMP
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IMP
    Golgi organization GO:0007030 IBA
    Golgi organization GO:0007030 IMP
    protein localization to organelle GO:0033365 IMP
    protein localization to Golgi apparatus GO:0034067 IMP
    protein stabilization GO:0050821 IMP
    glycosylation GO:0070085 IMP
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    nucleolus GO:0005730 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi transport complex GO:0017119 IBA
    Golgi transport complex GO:0017119 IDA
    Golgi transport complex GO:0017119 NAS
    trans-Golgi network membrane GO:0032588 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified COG7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
2 HNRNPD 3184
Two-hybrid Homo sapiens
3 C10orf76  
Synthetic Lethality Homo sapiens
4 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MUL1  
Affinity Capture-MS Homo sapiens
6 CYB5B 80777
Affinity Capture-MS Homo sapiens
7 EFNA4  
Affinity Capture-MS Homo sapiens
8 EBAG9 9166
Proximity Label-MS Homo sapiens
9 ENDOD1 23052
Affinity Capture-MS Homo sapiens
10 RAB1A 5861
Synthetic Lethality Homo sapiens
11 COMTD1 118881
Affinity Capture-MS Homo sapiens
12 GPR17 2840
Affinity Capture-MS Homo sapiens
13 Rhoa 11848
Affinity Capture-MS Mus musculus
14 TAX1BP1 8887
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 RAB1B 81876
Synthetic Lethality Homo sapiens
16 KIFC3 3801
Two-hybrid Homo sapiens
17 KIAA1715 80856
Affinity Capture-MS Homo sapiens
18 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NPTN 27020
Affinity Capture-MS Homo sapiens
21 STAM2 10254
Co-fractionation Homo sapiens
22 RP2 6102
Affinity Capture-MS Homo sapiens
23 CCHCR1  
Affinity Capture-MS Homo sapiens
24 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 COG8 84342
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
26 C9orf78 51759
Affinity Capture-MS Homo sapiens
27 CD40 958
Affinity Capture-MS Homo sapiens
28 ZNF471  
Two-hybrid Homo sapiens
29 COG2 22796
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
30 SNAPIN 23557
Affinity Capture-MS Homo sapiens
31 DUSP16  
Affinity Capture-MS Homo sapiens
32 ILVBL 10994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 COG1 9382
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
35 KRT7 3855
Co-fractionation Homo sapiens
36 CDK2 1017
Affinity Capture-MS Homo sapiens
37 TMEM43 79188
Affinity Capture-MS Homo sapiens
38 COG6 57511
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HSBP1 3281
Affinity Capture-MS Homo sapiens
40 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PHYHIP 9796
Affinity Capture-MS Homo sapiens
42 RPA3 6119
Proximity Label-MS Homo sapiens
43 NTRK1 4914
Affinity Capture-MS Homo sapiens
44 EGFR 1956
Affinity Capture-MS Homo sapiens
45 CLOCK  
Affinity Capture-MS Homo sapiens
46 TRAF5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
47 BIN3 55909
Affinity Capture-MS Homo sapiens
48 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 Poc1b  
Affinity Capture-MS Mus musculus
50 PKD2 5311
Affinity Capture-MS Homo sapiens
51 MAP4 4134
Co-fractionation Homo sapiens
52 COG3 83548
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
53 ACTB 60
Proximity Label-MS Homo sapiens
54 POC1B 282809
Affinity Capture-MS Homo sapiens
55 OCIAD1 54940
Affinity Capture-MS Homo sapiens
56 COG5 10466
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
57 COG4 25839
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
58 ARSF 416
Affinity Capture-MS Homo sapiens
59 RAB3GAP1 22930
Affinity Capture-MS Homo sapiens
60 Nek9  
Affinity Capture-MS Mus musculus
61 ITFG3 83986
Affinity Capture-MS Homo sapiens
62 PTAR1 375743
Synthetic Lethality Homo sapiens
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