Gene description for COG2
Gene name component of oligomeric golgi complex 2
Gene symbol COG2
Other names/aliases LDLC
Species Homo sapiens
 Database cross references - COG2
ExoCarta ExoCarta_22796
Vesiclepedia VP_22796
Entrez Gene 22796
HGNC 6546
MIM 606974
UniProt Q14746  
 COG2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for COG2
Molecular Function
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 IEA
Biological Process
    retrograde transport, vesicle recycling within Golgi GO:0000301 IMP
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 IMP
    Golgi organization GO:0007030 IBA
    Golgi organization GO:0007030 IMP
    protein transport GO:0015031 IEA
    glycosylation GO:0070085 IMP
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    Golgi stack GO:0005795 IDA
    Golgi transport complex GO:0017119 IBA
    Golgi transport complex GO:0017119 IDA
    Golgi transport complex GO:0017119 IMP
    Golgi transport complex GO:0017119 NAS
    trans-Golgi network membrane GO:0032588 TAS
 Experiment description of studies that identified COG2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 JCHAIN 3512
Affinity Capture-MS Homo sapiens
2 HNRNPD 3184
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CYB5B 80777
Affinity Capture-MS Homo sapiens
6 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 EBAG9 9166
Proximity Label-MS Homo sapiens
9 GPR17 2840
Affinity Capture-MS Homo sapiens
10 RAB7A 7879
Proximity Label-MS Homo sapiens
11 C9orf78 51759
Affinity Capture-MS Homo sapiens
12 RAB1B 81876
Affinity Capture-MS Homo sapiens
13 PSMA4 5685
Affinity Capture-MS Homo sapiens
14 C15orf59  
Affinity Capture-MS Homo sapiens
15 Iqgap3 404710
Affinity Capture-MS Mus musculus
16 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NPTN 27020
Affinity Capture-MS Homo sapiens
18 TEKT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SEMA4C 54910
Affinity Capture-MS Homo sapiens
20 IGHA1 3493
Affinity Capture-MS Homo sapiens
21 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 NUPL1 9818
Affinity Capture-MS Homo sapiens
23 COG8 84342
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
24 FPR1  
Affinity Capture-MS Homo sapiens
25 RNMT 8731
Co-fractionation Homo sapiens
26 CD40 958
Affinity Capture-MS Homo sapiens
27 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 BASP1 10409
Cross-Linking-MS (XL-MS) Homo sapiens
29 SLC18A2  
Affinity Capture-MS Homo sapiens
30 HNRNPA1 3178
Cross-Linking-MS (XL-MS) Homo sapiens
31 FASN 2194
Negative Genetic Homo sapiens
32 BPIFA2 140683
Affinity Capture-MS Homo sapiens
33 DUSP16  
Affinity Capture-MS Homo sapiens
34 OCIAD1 54940
Affinity Capture-MS Homo sapiens
35 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 COG1 9382
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
37 AMY1C 278
Affinity Capture-MS Homo sapiens
38 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RNASEH2A 10535
Affinity Capture-MS Homo sapiens
40 COG6 57511
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
41 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 Cyr61  
Affinity Capture-MS Mus musculus
43 ALOX5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 EXOSC2 23404
Cross-Linking-MS (XL-MS) Homo sapiens
45 RPA3 6119
Proximity Label-MS Homo sapiens
46 CST4 1472
Affinity Capture-MS Homo sapiens
47 NTRK1 4914
Affinity Capture-MS Homo sapiens
48 GPR45  
Affinity Capture-MS Homo sapiens
49 ATP6V1A 523
Co-fractionation Homo sapiens
50 ZG16B 124220
Affinity Capture-MS Homo sapiens
51 EFNA4  
Affinity Capture-MS Homo sapiens
52 GPR182  
Affinity Capture-MS Homo sapiens
53 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CDR2  
Affinity Capture-MS Homo sapiens
55 C6orf58  
Affinity Capture-MS Homo sapiens
56 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 COG3 83548
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
58 C3orf18  
Affinity Capture-MS Homo sapiens
59 CST2  
Affinity Capture-MS Homo sapiens
60 LRRC25  
Affinity Capture-MS Homo sapiens
61 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
62 SLC22A4 6583
Affinity Capture-MS Homo sapiens
63 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 MAPK8 5599
Affinity Capture-MS Homo sapiens
65 COG7 91949
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
66 LENG8  
Two-hybrid Homo sapiens
67 COG4 25839
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
68 ARSF 416
Affinity Capture-MS Homo sapiens
69 COG5 10466
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
70 PIGR 5284
Affinity Capture-MS Homo sapiens
71 ITFG3 83986
Affinity Capture-MS Homo sapiens
72 STMN1 3925
Cross-Linking-MS (XL-MS) Homo sapiens
73 IGHA2 3494
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here