Gene description for Iqgap3
Gene name IQ motif containing GTPase activating protein 3
Gene symbol Iqgap3
Other names/aliases AI593484
D030034H08
Species Mus musculus
 Database cross references - Iqgap3
ExoCarta ExoCarta_404710
Vesiclepedia VP_404710
Entrez Gene 404710
 Iqgap3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Iqgap3
Molecular Function
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 ISO
    small GTPase binding GO:0031267 IPI
    actin filament binding GO:0051015 IBA
    myosin VI light chain binding GO:0070856 ISO
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    positive regulation of protein phosphorylation GO:0001934 IMP
    protein phosphorylation GO:0006468 IMP
    Ras protein signal transduction GO:0007265 IMP
    regulation of cell size GO:0008361 IMP
    gene expression GO:0010467 IMP
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IMP
    mammary gland epithelial cell proliferation GO:0033598 IMP
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IMP
    positive regulation of MAPK cascade GO:0043410 IMP
    ERK1 and ERK2 cascade GO:0070371 IMP
    mitotic actomyosin contractile ring assembly actin filament organization GO:1903479 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cell-cell junction GO:0005911 IDA
    cell cortex GO:0005938 IBA
    lateral plasma membrane GO:0016328 IDA
 Experiment description of studies that identified Iqgap3 in exosomes
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Iqgap3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
3 MEF2A  
Affinity Capture-MS Homo sapiens
4 CDC42 998
Affinity Capture-MS Homo sapiens
5 ITGA1 3672
Affinity Capture-MS Homo sapiens
6 SRGAP3  
Affinity Capture-MS Homo sapiens
7 Kcna3  
Affinity Capture-MS Mus musculus
8 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
9 PLXNA3 55558
Affinity Capture-MS Homo sapiens
10 NPHP4 261734
Affinity Capture-MS Homo sapiens
11 ITPRIPL2 162073
Affinity Capture-MS Homo sapiens
12 COG2 22796
Affinity Capture-MS Homo sapiens
13 IARS2 55699
Affinity Capture-MS Homo sapiens
14 PPP1R16A 84988
Affinity Capture-MS Homo sapiens
15 Fancd2  
Affinity Capture-MS Mus musculus
16 HIVEP1 3096
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Iqgap3 is involved
No pathways found





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