Gene description for Iqgap3
Gene name IQ motif containing GTPase activating protein 3
Gene symbol Iqgap3
Other names/aliases AI593484
Species Mus musculus
 Database cross references - Iqgap3
ExoCarta ExoCarta_404710
Entrez Gene 404710
 Iqgap3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Iqgap3
Molecular Function
    Ras GTPase binding GO:0017016 IPI
    Rho GTPase binding GO:0017048 IPI
    myosin VI light chain binding GO:0070856 ISO
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 ISO
Biological Process
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IMP
    negative regulation of gene expression GO:0010629 IMP
    regulation of cell size GO:0008361 IMP
    positive regulation of protein phosphorylation GO:0001934 IMP
    ERK1 and ERK2 cascade GO:0070371 IMP
    positive regulation of gene expression GO:0010628 IMP
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    cellular response to organic substance GO:0071310 IDA
    activation of MAPK activity GO:0000187 IMP
    Ras protein signal transduction GO:0007265 IMP
Subcellular Localization
    lateral plasma membrane GO:0016328 IDA
    cell-cell junction GO:0005911 IDA
    cytoplasm GO:0005737 IDA
    intracellular GO:0005622 IMP
 Experiment description of studies that identified Iqgap3 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Iqgap3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Iqgap3 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here