Gene description for ZCCHC6
Gene name zinc finger, CCHC domain containing 6
Gene symbol ZCCHC6
Other names/aliases PAPD6
TUT7
Species Homo sapiens
 Database cross references - ZCCHC6
ExoCarta ExoCarta_79670
Vesiclepedia VP_79670
Entrez Gene 79670
HGNC 25817
MIM 613467
UniProt Q5VYS8  
 ZCCHC6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZCCHC6
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    miRNA binding GO:0035198 IDA
    RNA uridylyltransferase activity GO:0050265 IBA
    RNA uridylyltransferase activity GO:0050265 IDA
    uridylyltransferase activity GO:0070569 IDA
Biological Process
    oocyte maturation GO:0001556 ISS
    miRNA metabolic process GO:0010586 IDA
    pre-miRNA processing GO:0031054 IDA
    RNA 3'-end processing GO:0031123 IDA
    histone mRNA catabolic process GO:0071044 IMP
    RNA 3' uridylation GO:0071076 IBA
    RNA 3' uridylation GO:0071076 IDA
    RNA 3' uridylation GO:0071076 ISS
    transposable element silencing by mRNA destabilization GO:0141008 IDA
    polyuridylation-dependent mRNA catabolic process GO:1990074 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified ZCCHC6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZCCHC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF668  
Affinity Capture-MS Homo sapiens
2 RPL26L1 51121
Affinity Capture-MS Homo sapiens
3 Cyr61  
Affinity Capture-MS Mus musculus
4 XPC  
Co-fractionation Homo sapiens
5 Iqgap3 404710
Affinity Capture-MS Mus musculus
6 RPL13A 23521
Affinity Capture-MS Homo sapiens
7 MKNK2 2872
Affinity Capture-MS Homo sapiens
8 RPL15 6138
Affinity Capture-MS Homo sapiens
9 FGF3  
Affinity Capture-MS Homo sapiens
10 SOX2  
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 RPS3 6188
Affinity Capture-MS Homo sapiens
13 RPL10A 4736
Affinity Capture-MS Homo sapiens
14 DIAPH1 1729
Affinity Capture-MS Homo sapiens
15 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 CCDC137  
Affinity Capture-MS Homo sapiens
18 RPS10 6204
Affinity Capture-MS Homo sapiens
19 ANOS1 3730
Affinity Capture-MS Homo sapiens
20 FBL 2091
Proximity Label-MS Homo sapiens
21 OBSL1 23363
Affinity Capture-MS Homo sapiens
22 KDR  
Affinity Capture-MS Homo sapiens
23 ADARB1 104
Affinity Capture-MS Homo sapiens
24 PRKRA 8575
Affinity Capture-MS Homo sapiens
25 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TOMM40 10452
Co-fractionation Homo sapiens
27 MYCN  
Affinity Capture-MS Homo sapiens
28 OASL 8638
Affinity Capture-MS Homo sapiens
29 KIF14 9928
Affinity Capture-MS Homo sapiens
30 LIN28A  
Affinity Capture-MS Homo sapiens
31 ZDHHC17 23390
Two-hybrid Homo sapiens
32 DDX21 9188
Affinity Capture-MS Homo sapiens
33 LIN28B  
Affinity Capture-MS Homo sapiens
34 RPL4 6124
Affinity Capture-MS Homo sapiens
35 ZBTB47  
Affinity Capture-MS Homo sapiens
36 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
37 PURG  
Affinity Capture-MS Homo sapiens
38 NOP2 4839
Affinity Capture-MS Homo sapiens
39 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CCNB1 891
Affinity Capture-MS Homo sapiens
41 RPL31 6160
Affinity Capture-MS Homo sapiens
42 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
43 PLK1 5347
Affinity Capture-MS Homo sapiens
44 CBX6  
Affinity Capture-MS Homo sapiens
45 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
46 MB21D1  
Proximity Label-MS Homo sapiens
47 HECTD1 25831
Affinity Capture-MS Homo sapiens
48 MAGEB2 4113
Affinity Capture-MS Homo sapiens
49 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RMDN3 55177
Proximity Label-MS Homo sapiens
51 CCDC59  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ATG16L1 55054
Affinity Capture-MS Homo sapiens
53 ABT1 29777
Affinity Capture-MS Homo sapiens
54 ATL3 25923
Affinity Capture-MS Homo sapiens
55 EIF6 3692
Proximity Label-MS Homo sapiens
56 SIRT7  
Affinity Capture-MS Homo sapiens
57 POLK  
Affinity Capture-MS Homo sapiens
58 SURF6  
Affinity Capture-MS Homo sapiens
59 PCIF1 63935
Affinity Capture-MS Homo sapiens
60 RPL3 6122
Affinity Capture-MS Homo sapiens
61 RPL7L1 285855
Affinity Capture-MS Homo sapiens
62 Cep152  
Affinity Capture-MS Mus musculus
63 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PCDH7 5099
Affinity Capture-MS Homo sapiens
65 MAPRE3  
Proximity Label-MS Homo sapiens
66 RPL36 25873
Affinity Capture-MS Homo sapiens
67 RPS13 6207
Affinity Capture-MS Homo sapiens
68 Kif13b  
Affinity Capture-MS Mus musculus
69 ZNF653  
Affinity Capture-MS Homo sapiens
70 Rpl35 66489
Affinity Capture-MS Mus musculus
71 H2AFB2  
Affinity Capture-MS Homo sapiens
72 DDX55  
Affinity Capture-MS Homo sapiens
73 RPS16 6217
Affinity Capture-MS Homo sapiens
74 RPL13 6137
Affinity Capture-MS Homo sapiens
75 Tor1aip1  
Affinity Capture-MS Mus musculus
76 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
77 SIRT6  
Affinity Capture-MS Homo sapiens
78 FBXL6  
Proximity Label-MS Homo sapiens
79 RPL6 6128
Affinity Capture-MS Homo sapiens
80 DGCR8  
Affinity Capture-MS Homo sapiens
81 ZNF48  
Affinity Capture-MS Homo sapiens
82 QSOX2 169714
Affinity Capture-MS Homo sapiens
83 TOMM5  
Co-fractionation Homo sapiens
84 RPL28 6158
Affinity Capture-MS Homo sapiens
85 SERBP1 26135
Proximity Label-MS Homo sapiens
86 CUL7 9820
Affinity Capture-MS Homo sapiens
87 SLBP  
Affinity Capture-MS Homo sapiens
88 VDAC3 7419
Co-fractionation Homo sapiens
89 ZNF467  
Affinity Capture-MS Homo sapiens
90 TIMM13 26517
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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