Gene description for PCDH7
Gene name protocadherin 7
Gene symbol PCDH7
Other names/aliases BH-Pcdh
BHPCDH
PPP1R120
Species Homo sapiens
 Database cross references - PCDH7
ExoCarta ExoCarta_5099
Vesiclepedia VP_5099
Entrez Gene 5099
HGNC 8659
MIM 602988
UniProt O60245  
 PCDH7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PCDH7
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    platelet alpha granule membrane GO:0031092 TAS
 Experiment description of studies that identified PCDH7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PCDH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCG2 9429
Affinity Capture-MS Homo sapiens
2 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RBPJL  
Affinity Capture-MS Homo sapiens
4 CYBRD1 79901
Affinity Capture-MS Homo sapiens
5 NT5E 4907
Co-fractionation Homo sapiens
6 FCGR1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 Rab5c 19345
Affinity Capture-MS Mus musculus
8 RAB35 11021
Proximity Label-MS Homo sapiens
9 CEP350 9857
Affinity Capture-MS Homo sapiens
10 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SIRT6  
Affinity Capture-MS Homo sapiens
12 EBAG9 9166
Proximity Label-MS Homo sapiens
13 PSMD5 5711
Affinity Capture-MS Homo sapiens
14 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CSTL1  
Affinity Capture-MS Homo sapiens
16 C2orf48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LAMTOR1 55004
Proximity Label-MS Homo sapiens
18 MARCKS 4082
Proximity Label-MS Homo sapiens
19 KLK5 25818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RPS14P3  
Affinity Capture-MS Homo sapiens
21 TNF  
Affinity Capture-MS Homo sapiens
22 GJA1 2697
Proximity Label-MS Homo sapiens
23 FCGRT 2217
Affinity Capture-MS Homo sapiens
24 PCDH12 51294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 EPB41L4A 64097
Proximity Label-MS Homo sapiens
26 LAMP1 3916
Proximity Label-MS Homo sapiens
27 DCDC1  
Affinity Capture-MS Homo sapiens
28 CC2D1B 200014
Affinity Capture-MS Homo sapiens
29 GOLT1B 51026
Affinity Capture-MS Homo sapiens
30 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SPSB4  
Affinity Capture-MS Homo sapiens
32 UCN3  
Affinity Capture-MS Homo sapiens
33 GJD3  
Proximity Label-MS Homo sapiens
34 CAPZA1 829
Affinity Capture-MS Homo sapiens
35 LAMP2 3920
Proximity Label-MS Homo sapiens
36 ADAMTS13 11093
Affinity Capture-MS Homo sapiens
37 ARF6 382
Proximity Label-MS Homo sapiens
38 STX4 6810
Proximity Label-MS Homo sapiens
39 C11orf52 91894
Proximity Label-MS Homo sapiens
40 OCLN 100506658
Proximity Label-MS Homo sapiens
41 LYN 4067
Proximity Label-MS Homo sapiens
42 DDX39A 10212
Affinity Capture-MS Homo sapiens
43 DNAJC5 80331
Proximity Label-MS Homo sapiens
44 EPHA2 1969
Proximity Label-MS Homo sapiens
45 LAG3  
Affinity Capture-MS Homo sapiens
46 SP7  
Affinity Capture-MS Homo sapiens
47 RAB2A 5862
Proximity Label-MS Homo sapiens
48 CMSS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MLLT4 4301
Proximity Label-MS Homo sapiens
50 SP1  
Affinity Capture-MS Homo sapiens
51 DIRAS3  
Proximity Label-MS Homo sapiens
52 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
53 RAB7A 7879
Proximity Label-MS Homo sapiens
54 NXPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RAB11A 8766
Proximity Label-MS Homo sapiens
56 XAGE1B  
Affinity Capture-MS Homo sapiens
57 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
58 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 LAMP3  
Proximity Label-MS Homo sapiens
60 CHP2  
Affinity Capture-MS Homo sapiens
61 RAF1 5894
Affinity Capture-MS Homo sapiens
62 CAPZA2 830
Affinity Capture-MS Homo sapiens
63 HUS1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 HNRNPU 3192
Co-fractionation Homo sapiens
65 DTWD2  
Affinity Capture-MS Homo sapiens
66 KRAS 3845
Proximity Label-MS Homo sapiens
67 RNF113A 7737
Affinity Capture-MS Homo sapiens
68 NUP210P1  
Affinity Capture-MS Homo sapiens
69 DNAJC12  
Affinity Capture-MS Homo sapiens
70 CAV1 857
Proximity Label-MS Homo sapiens
71 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CTDSPL 10217
Proximity Label-MS Homo sapiens
73 RHOB 388
Proximity Label-MS Homo sapiens
74 C2CD4B  
Affinity Capture-MS Homo sapiens
75 DDX28  
Co-fractionation Homo sapiens
76 XRCC5 7520
Affinity Capture-MS Homo sapiens
77 STX6 10228
Proximity Label-MS Homo sapiens
78 MARCKSL1 65108
Co-fractionation Homo sapiens
79 TACC3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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