Gene description for BPIFA2
Gene name BPI fold containing family A, member 2
Gene symbol BPIFA2
Other names/aliases C20orf70
PSP
SPLUNC2
bA49G10.1
Species Homo sapiens
 Database cross references - BPIFA2
ExoCarta ExoCarta_140683
Vesiclepedia VP_140683
Entrez Gene 140683
HGNC 16203
UniProt Q96DR5  
 BPIFA2 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for BPIFA2
Molecular Function
    lipopolysaccharide binding GO:0001530 IBA
    lipopolysaccharide binding GO:0001530 IDA
    protein binding GO:0005515 IPI
Biological Process
    defense response to bacterium GO:0042742 IEA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    secretory granule GO:0030141 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified BPIFA2 in exosomes
1
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for BPIFA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 JAK2 3717
Affinity Capture-MS Homo sapiens
2 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HBQ1  
Affinity Capture-MS Homo sapiens
4 PLEKHG6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 STK11 6794
Affinity Capture-MS Homo sapiens
6 AGTRAP 57085
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 KIR2DS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HINT2 84681
Affinity Capture-MS Homo sapiens
9 TIMM10  
Affinity Capture-MS Homo sapiens
10 SRRT 51593
Affinity Capture-MS Homo sapiens
11 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCDC174  
Affinity Capture-MS Homo sapiens
13 RHOBTB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ZNF321P  
Affinity Capture-MS Homo sapiens
15 UQCRQ 27089
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ZNF491  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NKAP 79576
Affinity Capture-MS Homo sapiens
18 COG2 22796
Affinity Capture-MS Homo sapiens
19 PRKCE 5581
Affinity Capture-MS Homo sapiens
20 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CRH  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BPIFA2 is involved
PathwayEvidenceSource
Antimicrobial peptides TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome





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