Gene description for STK11
Gene name serine/threonine kinase 11
Gene symbol STK11
Other names/aliases LKB1
PJS
hLKB1
Species Homo sapiens
 Database cross references - STK11
ExoCarta ExoCarta_6794
Vesiclepedia VP_6794
Entrez Gene 6794
HGNC 11389
MIM 602216
UniProt Q15831  
 STK11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for STK11
Molecular Function
    protein kinase activator activity GO:0030295 IDA
    magnesium ion binding GO:0000287 IDA
    p53 binding GO:0002039 IDA
    LRR domain binding GO:0030275 IEA
    protein serine/threonine kinase activity GO:0004674 TAS
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 IEA
    ATP binding GO:0005524 IDA
Biological Process
    positive regulation of axonogenesis GO:0050772 IEA
    positive regulation of gluconeogenesis GO:0045722 IEA
    regulation of Wnt signaling pathway GO:0030111 IEA
    small molecule metabolic process GO:0044281 TAS
    cell cycle arrest GO:0007050 TAS
    protein autophosphorylation GO:0046777 IDA
    TCR signalosome assembly GO:0036399 IEA
    spermatid development GO:0007286 IEA
    negative regulation of cell growth GO:0030308 ISS
    cellular response to DNA damage stimulus GO:0006974 IMP
    canonical Wnt signaling pathway GO:0060070 IEA
    response to ionizing radiation GO:0010212 ISS
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IDA
    protein phosphorylation GO:0006468 IDA
    regulation of cell growth GO:0001558 ISS
    regulation of protein kinase B signaling GO:0051896 IEA
    cellular response to UV-B GO:0071493 IDA
    tissue homeostasis GO:0001894 IEA
    establishment of cell polarity GO:0030010 ISS
    regulation of fatty acid biosynthetic process GO:0042304 TAS
    protein heterooligomerization GO:0051291 IEA
    response to lipid GO:0033993 IEA
    vasculature development GO:0001944 ISS
    positive thymic T cell selection GO:0045059 IEA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP
    Golgi localization GO:0051645 IEA
    anoikis GO:0043276 IMP
    axonogenesis GO:0007409 IEA
    glucose homeostasis GO:0042593 ISS
    T cell receptor signaling pathway GO:0050852 IEA
    energy reserve metabolic process GO:0006112 TAS
    response to glucagon GO:0033762 IEA
    insulin receptor signaling pathway GO:0008286 TAS
    autophagy GO:0006914 IEA
    negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    negative regulation of cell proliferation GO:0008285 IMP
    activation of protein kinase activity GO:0032147 IEA
Subcellular Localization
    membrane GO:0016020 ISS
    extracellular exosome GO:0070062 IDA
    TCR signalosome GO:0036398 IEA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified STK11 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for STK11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAB39 51719
Affinity Capture-Western Homo sapiens
2 CDC37 11140
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 STK11IP 114790
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
4 SMARCA4 6597
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 STRADA 92335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which STK11 is involved
PathwayEvidenceSource
AMPK inhibits chREBP transcriptional activation activity TAS Reactome
Regulation of AMPK activity via LKB1 TAS Reactome





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