ExoCarta: Gene summary

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Gene description for STK11
Gene name	serine/threonine kinase 11
Gene symbol	STK11
Other names/aliases	LKB1 PJS hLKB1
Species	Homo sapiens
Database cross references - STK11
ExoCarta	ExoCarta_6794
Vesiclepedia	VP_6794
Entrez Gene	6794
HGNC	11389
MIM	602216
UniProt	Q15831
STK11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Urine	19056867

Gene ontology annotations for STK11

Molecular Function
	magnesium ion binding	GO:0000287	IDA
	p53 binding	GO:0002039	IDA
	protein serine/threonine kinase activity	GO:0004674	IBA
	protein serine/threonine kinase activity	GO:0004674	IDA
	protein serine/threonine kinase activity	GO:0004674	TAS
	3-phosphoinositide-dependent protein kinase activity	GO:0004676	IEA
	DNA-dependent protein kinase activity	GO:0004677	IEA
	AMP-activated protein kinase activity	GO:0004679	IEA
	eukaryotic translation initiation factor 2alpha kinase activity	GO:0004694	IEA
	ribosomal protein S6 kinase activity	GO:0004711	IEA
	protein binding	GO:0005515	IPI
	ATP binding	GO:0005524	IDA
	LRR domain binding	GO:0030275	IEA
	protein kinase activator activity	GO:0030295	IDA
	histone H3S10 kinase activity	GO:0035175	IEA
	histone H3T11 kinase activity	GO:0035402	IEA
	histone H3T6 kinase activity	GO:0035403	IEA
	histone H2AXS139 kinase activity	GO:0035979	IEA
	histone H3S28 kinase activity	GO:0044022	IEA
	histone H4S1 kinase activity	GO:0044023	IEA
	histone H2AS1 kinase activity	GO:0044024	IEA
	histone H2BS14 kinase activity	GO:0044025	IEA
	protein-containing complex binding	GO:0044877	IEA
	histone H3T3 kinase activity	GO:0072354	IEA
	histone H2AS121 kinase activity	GO:0072371	IEA
	Rho-dependent protein serine/threonine kinase activity	GO:0072518	IEA
	protein serine kinase activity	GO:0106310	IEA
	histone H2BS36 kinase activity	GO:0140823	IEA
	histone H3S57 kinase activity	GO:0140855	IEA
	histone H3T45 kinase activity	GO:0140857	IEA
	histone H2AT120 kinase activity	GO:1990244	IEA
Biological Process
	regulation of cell growth	GO:0001558	ISS
	tissue homeostasis	GO:0001894	IEA
	vasculature development	GO:0001944	ISS
	chromatin remodeling	GO:0006338	IEA
	protein phosphorylation	GO:0006468	IDA
	protein dephosphorylation	GO:0006470	IMP
	autophagy	GO:0006914	IEA
	DNA damage response	GO:0006974	IBA
	DNA damage response	GO:0006974	IMP
	signal transduction	GO:0007165	IBA
	spermatogenesis	GO:0007283	IEA
	axonogenesis	GO:0007409	IEA
	negative regulation of cell population proliferation	GO:0008285	IMP
	response to ionizing radiation	GO:0010212	ISS
	positive regulation of autophagy	GO:0010508	IMP
	response to activity	GO:0014823	IEA
	peptidyl-threonine phosphorylation	GO:0018107	IDA
	establishment of cell polarity	GO:0030010	IBA
	establishment of cell polarity	GO:0030010	IMP
	establishment of cell polarity	GO:0030010	ISS
	regulation of Wnt signaling pathway	GO:0030111	IBA
	negative regulation of cell growth	GO:0030308	ISS
	positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	IMP
	activation of protein kinase activity	GO:0032147	IDA
	activation of protein kinase activity	GO:0032147	IMP
	response to glucagon	GO:0033762	IEA
	response to lipid	GO:0033993	IEA
	protein localization to nucleus	GO:0034504	IEA
	glucose homeostasis	GO:0042593	ISS
	anoikis	GO:0043276	IMP
	positive thymic T cell selection	GO:0045059	IEA
	positive regulation of gluconeogenesis	GO:0045722	IEA
	protein autophosphorylation	GO:0046777	IDA
	regulation of dendrite morphogenesis	GO:0048814	IEA
	positive regulation of axonogenesis	GO:0050772	IEA
	T cell receptor signaling pathway	GO:0050852	IEA
	Golgi localization	GO:0051645	IEA
	regulation of cell cycle	GO:0051726	TAS
	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO:0051896	IEA
	epithelial cell proliferation involved in prostate gland development	GO:0060767	IEA
	negative regulation of epithelial cell proliferation involved in prostate gland development	GO:0060770	IEA
	G1 to G0 transition	GO:0070314	IDA
	G1 to G0 transition	GO:0070314	IPI
	cellular response to UV-B	GO:0071493	IDA
	intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	IDA
	negative regulation of canonical Wnt signaling pathway	GO:0090090	IMP
	response to thyroid hormone	GO:0097066	IEA
	dendrite extension	GO:0097484	IEA
	negative regulation of cold-induced thermogenesis	GO:0120163	ISS
	positive regulation of protein localization to nucleus	GO:1900182	IEA
	positive regulation of vesicle transport along microtubule	GO:1901610	IBA
	positive regulation of vesicle transport along microtubule	GO:1901610	IMP
	regulation of signal transduction by p53 class mediator	GO:1901796	TAS
	negative regulation of TORC1 signaling	GO:1904262	IMP
Subcellular Localization
	nucleus	GO:0005634	IBA
	nucleus	GO:0005634	IDA
	nucleoplasm	GO:0005654	IDA
	nucleoplasm	GO:0005654	TAS
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IDA
	cytoplasm	GO:0005737	ISS
	mitochondrion	GO:0005739	IDA
	cytosol	GO:0005829	IDA
	cytosol	GO:0005829	ISS
	cytosol	GO:0005829	TAS
	membrane	GO:0016020	ISS
	Z disc	GO:0030018	IEA
	extracellular exosome	GO:0070062	HDA
	intracellular protein-containing complex	GO:0140535	IDA
	serine/threonine protein kinase complex	GO:1902554	IPI
	serine/threonine protein kinase complex	GO:1902554	ISS

Experiment description of studies that identified STK11 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

MISEV standards
✘	Biophysical techniques
✔ AQP2	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

19056867

Organism

Homo sapiens

Experiment description

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Authors

"Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"

Journal name

JASN

Publication year

2009

Sample

Urine

Sample name

Urine - Normal

Isolation/purification methods

Differential centrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry [LTQ]
Western blotting

Protein-protein interactions for STK11

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

PRTN3

5657

Affinity Capture-MS

Homo sapiens

Ap2m1

11773

Two-hybrid

Mus musculus

PRKAA1

5562

Two-hybrid		Homo sapiens
Biochemical Activity		Homo sapiens

WDR6

11180

Affinity Capture-Western

Homo sapiens

BIRC6

57448

Negative Genetic

Homo sapiens

LYZ

4069

Affinity Capture-MS

Homo sapiens

SPRR3

6707

Affinity Capture-MS

Homo sapiens

TSC2

7249

Negative Genetic

Homo sapiens

ATG9A

79065

Negative Genetic

Homo sapiens

MCM9

254394

Negative Genetic

Homo sapiens

DNTTIP1

116092

Negative Genetic

Homo sapiens

CSNK1A1

1452

Negative Genetic

Homo sapiens

OTP

Negative Genetic

Homo sapiens

SERPINB13

5275

Affinity Capture-MS

Homo sapiens

LIMS1

3987

Affinity Capture-MS

Homo sapiens

PACSIN2

11252

Affinity Capture-MS

Homo sapiens

MPO

4353

Affinity Capture-MS

Homo sapiens

HSP90AB1

3326

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ATM

472

Affinity Capture-Western

Homo sapiens

KDM4A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NDUFB6

4712

Negative Genetic

Homo sapiens

APP

351

Reconstituted Complex

Homo sapiens

CAB39

51719

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

HAL

3034

Affinity Capture-MS

Homo sapiens

PPL

5493

Affinity Capture-MS

Homo sapiens

WDR48

57599

Affinity Capture-MS

Homo sapiens

KIF23

9493

Affinity Capture-MS

Homo sapiens

SDHB

6390

Negative Genetic

Homo sapiens

SERPINB4

6318

Affinity Capture-MS

Homo sapiens

DHX35

Negative Genetic

Homo sapiens

AGGF1

Affinity Capture-MS

Homo sapiens

COPS5

10987

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

BRCC3

79184

Negative Genetic

Homo sapiens

TBC1D23

55773

Two-hybrid

Homo sapiens

DNASE1

Negative Genetic

Homo sapiens

SUPT5H

6829

Affinity Capture-MS

Homo sapiens

STK11IP

114790

Affinity Capture-Western

Homo sapiens

FBXW8

26259

Affinity Capture-MS

Homo sapiens

DDX58

23586

Affinity Capture-RNA

Homo sapiens

YPEL5

51646

Negative Genetic

Homo sapiens

JTB

10899

Negative Genetic

Homo sapiens

SERPINB1

1992

Affinity Capture-MS

Homo sapiens

FLG

2312

Affinity Capture-MS

Homo sapiens

PRKRA

8575

Negative Genetic

Homo sapiens

SPDEF

Two-hybrid

Homo sapiens

HERC2

8924

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

DSG3

1830

Affinity Capture-MS

Homo sapiens

ETV4

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Biochemical Activity		Homo sapiens

ENDOU

Affinity Capture-MS

Homo sapiens

IVD

3712

Affinity Capture-MS

Homo sapiens

JCHAIN

3512

Affinity Capture-MS

Homo sapiens

SLC30A9

10463

Negative Genetic

Homo sapiens

MARK4

Affinity Capture-Western

Homo sapiens

EIF2B1

1967

Affinity Capture-Western

Homo sapiens

GBP6

163351

Affinity Capture-MS

Homo sapiens

MLXIPL

Affinity Capture-MS

Homo sapiens

DVL2

1856

Affinity Capture-MS

Homo sapiens

GSK3B

2932

Affinity Capture-Western

Homo sapiens

SLC25A33

Negative Genetic

Homo sapiens

BPIFB2

Affinity Capture-MS

Homo sapiens

CST2

Affinity Capture-MS

Homo sapiens

FAM106A

Negative Genetic

Homo sapiens

SCEL

8796

Affinity Capture-MS

Homo sapiens

HSP90AB4P

664618

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POF1B

79983

Affinity Capture-MS

Homo sapiens

PIP4K2C

79837

Affinity Capture-MS

Homo sapiens

BRIP1

Negative Genetic

Homo sapiens

IL1RN

3557

Affinity Capture-MS

Homo sapiens

TRIM26

7726

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

UBE2T

Negative Genetic

Homo sapiens

IGHA2

3494

Affinity Capture-MS

Homo sapiens

USP11

8237

Affinity Capture-MS

Homo sapiens

LZTS1

Negative Genetic

Homo sapiens

MPV17

4358

Negative Genetic

Homo sapiens

STRADA

92335

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

GTPBP1

9567

Negative Genetic

Homo sapiens

MAPRE1

22919

Two-hybrid

Homo sapiens

BAG6

7917

Negative Genetic

Homo sapiens

RNF146

Affinity Capture-Western

Homo sapiens

KPNA4

3840

Negative Genetic

Homo sapiens

RPS6KB1

6198

Co-localization

Homo sapiens

SMARCA4

6597

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

PDS5A

23244

Negative Genetic

Homo sapiens

MTFMT

Negative Genetic

Homo sapiens

MUC5B

Affinity Capture-MS

Homo sapiens

HTATSF1

27336

Affinity Capture-MS

Homo sapiens

PIGR

5284

Affinity Capture-MS

Homo sapiens

INO80E

Affinity Capture-MS

Homo sapiens

EVPL

2125

Affinity Capture-MS

Homo sapiens

COPS3

8533

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TGM1

7051

Affinity Capture-MS

Homo sapiens

BTK

695

Negative Genetic

Homo sapiens

KLK10

5655

Affinity Capture-MS

Homo sapiens

TYMS

7298

Negative Genetic

Homo sapiens

MTMR4

Affinity Capture-MS

Homo sapiens

ANXA8

653145

Affinity Capture-MS

Homo sapiens

CRNN

49860

Affinity Capture-MS

Homo sapiens

BCLAF1

9774

Negative Genetic

Homo sapiens

C8orf76

Negative Genetic

Homo sapiens

100

SERPINB3

6317

Affinity Capture-MS

Homo sapiens

101

IVL

3713

Affinity Capture-MS

Homo sapiens

102

Eif2b1

Two-hybrid

Mus musculus

103

MUC7

4589

Affinity Capture-MS

Homo sapiens

104

IGHA1

3493

Affinity Capture-MS

Homo sapiens

105

TNKS

8658

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

106

C6orf58

Affinity Capture-MS

Homo sapiens

107

AKAP9

10142

Affinity Capture-MS

Homo sapiens

108

PRKAA2

5563

Co-localization

Homo sapiens

109

ANXA1

301

Affinity Capture-MS

Homo sapiens

110

SETD2

Affinity Capture-MS

Homo sapiens

111

CST1

Affinity Capture-MS

Homo sapiens

112

CSNK2A1

1457

Synthetic Lethality

Homo sapiens

113

HSP90AB3P

3327

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

TNKS2

80351

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

115

BAP1

8314

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

116

SERPINB5

5268

Affinity Capture-MS

Homo sapiens

117

TNIP2

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

118

SNX9

51429

Affinity Capture-MS

Homo sapiens

119

AP2M1

1173

Affinity Capture-Western

Homo sapiens

120

AMY1C

278

Affinity Capture-MS

Homo sapiens

121

FBXW11

Negative Genetic

Homo sapiens

122

FKBP5

2289

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

PIP4K2A

5305

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

124

HSP90AA4P

3323

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

125

CST4

1472

Affinity Capture-MS

Homo sapiens

126

SIK1

Biochemical Activity

Homo sapiens

127

CAMSAP1

157922

Negative Genetic

Homo sapiens

128

TP63

Affinity Capture-Western

Homo sapiens

129

HSP90AA5P

730211

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

130

HSPA1A

3303

Affinity Capture-MS

Homo sapiens

131

RPAP3

79657

Affinity Capture-MS

Homo sapiens

132

CUL7

9820

Affinity Capture-MS

Homo sapiens

133

BPIFA2

140683

Affinity Capture-MS

Homo sapiens

134

UBE2D2

7322

Biochemical Activity

Homo sapiens

135

PDSS1

Negative Genetic

Homo sapiens

136

BRD9

65980

Negative Genetic

Homo sapiens

137

MDM2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

138

S100A9

6280

Affinity Capture-MS

Homo sapiens

139

H2AFX

3014

Affinity Capture-MS

Homo sapiens

140

DMBT1

1755

Affinity Capture-MS

Homo sapiens

141

STUB1

10273

Affinity Capture-Western

Homo sapiens

142

FBXO42

Negative Genetic

Homo sapiens

143

NES

10763

Affinity Capture-MS

Homo sapiens

144

CA6

765

Affinity Capture-MS

Homo sapiens

145

FAM175B

23172

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

146

ARID2

Negative Genetic

Homo sapiens

147

SNAI1

Affinity Capture-Western

Homo sapiens

148

TP53

7157

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

149

A2ML1

144568

Affinity Capture-MS

Homo sapiens

150

C5orf24

134553

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

151

SMARCC1

6599

Affinity Capture-MS

Homo sapiens

152

STRADB

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

153

CDC37

11140

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

154

IKBKG

8517

Negative Genetic

Homo sapiens

155

FBXL14

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

156

ATG101

Negative Genetic

Homo sapiens

157

FYCO1

79443

Affinity Capture-MS

Homo sapiens

158

HSP90AA1

3320

Affinity Capture-Luminescence		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

159

SNRK

Biochemical Activity

Homo sapiens

160

SIRT1

Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

161

MAP2K1

5604

Synthetic Lethality

Homo sapiens

162

BABAM1

29086

Affinity Capture-MS

Homo sapiens

163

FBXO41

Negative Genetic

Homo sapiens

164

RBM4

5936

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

165

HOXC9

Negative Genetic

Homo sapiens

166

RIOK2

55781

Affinity Capture-MS

Homo sapiens

167

PPP2R3C

Negative Genetic

Homo sapiens

168

TGM3

7053

Affinity Capture-MS

Homo sapiens

169

SUPT6H

6830

Affinity Capture-MS

Homo sapiens

170

MARK2

2011

Biochemical Activity

Homo sapiens

171

FANCF

Negative Genetic

Homo sapiens

172

ZG16B

124220

Affinity Capture-MS

Homo sapiens

173

PSMF1

9491

Negative Genetic

Homo sapiens

174

RPRD1B

58490

Negative Genetic

Homo sapiens

175

PEX5

5830

Affinity Capture-MS

Homo sapiens

176

CCDC136

Affinity Capture-MS

Homo sapiens

177

LTF

4057

Affinity Capture-MS

Homo sapiens

178

COPS4

51138

Affinity Capture-MS

Homo sapiens

179

GTPBP2

54676

Negative Genetic

Homo sapiens

180

NEMF

9147

Affinity Capture-MS

Homo sapiens

181

CAB39L

81617

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

182

SULT2B1

6820

Affinity Capture-MS

Homo sapiens

183

FANCA

Negative Genetic

Homo sapiens

184

SOX18

54345

Negative Genetic

Homo sapiens

View the network

Pathways in which STK11 is involved

Pathway	Evidence	Source
AMPK inhibits chREBP transcriptional activation activity	IEA	Reactome
Energy dependent regulation of mTOR by LKB1-AMPK	TAS	Reactome
FOXO-mediated transcription	TAS	Reactome
FOXO-mediated transcription of cell death genes	TAS	Reactome
Gene expression (Transcription)	TAS	Reactome
Generic Transcription Pathway	TAS	Reactome
Integration of energy metabolism	IEA	Reactome
Metabolism	IEA	Reactome
MTOR signalling	TAS	Reactome
Regulation of TP53 Activity	TAS	Reactome
Regulation of TP53 Activity through Phosphorylation	TAS	Reactome
RNA Polymerase II Transcription	TAS	Reactome
Signal Transduction	TAS	Reactome
Transcriptional Regulation by TP53	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here