Gene description for GBP6
Gene name guanylate binding protein family, member 6
Gene symbol GBP6
Other names/aliases -
Species Homo sapiens
 Database cross references - GBP6
ExoCarta ExoCarta_163351
Vesiclepedia VP_163351
Entrez Gene 163351
HGNC 25395
MIM 612467
UniProt Q6ZN66  
 GBP6 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for GBP6
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
Biological Process
    immune response GO:0006955 ISS
    defense response to bacterium GO:0042742 ISS
    defense response to protozoan GO:0042832 IBA
    defense response to Gram-positive bacterium GO:0050830 IBA
    cellular response to type II interferon GO:0071346 IBA
    cellular response to type II interferon GO:0071346 ISS
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified GBP6 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for GBP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 STK11 6794
Affinity Capture-MS Homo sapiens
3 HSF2  
Affinity Capture-MS Homo sapiens
4 SRRT 51593
Affinity Capture-MS Homo sapiens
5 GBP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TP53 7157
Affinity Capture-MS Homo sapiens
8 SIRT5 23408
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GBP6 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





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