Gene description for GBP6
Gene name guanylate binding protein family, member 6
Gene symbol GBP6
Other names/aliases -
Species Homo sapiens
 Database cross references - GBP6
ExoCarta ExoCarta_163351
Entrez Gene 163351
HGNC 25395
MIM 612467
UniProt Q6ZN66  
 GBP6 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for GBP6
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
Biological Process
    cellular response to interferon-gamma GO:0071346 ISS
    metabolic process GO:0008152 IEA
    immune response GO:0006955 ISS
    defense response to bacterium GO:0042742 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GBP6 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for GBP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GBP6 is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome





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