Experiment description of studies that identified DNTTIP1 in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

2 Experiment ID 237 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocytes Sample name MIHA Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RNA Sequencing

Protein-protein interactions for DNTTIP1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 TLX1   Proximity Label-MS Homo sapiens 2 FOXF2   Affinity Capture-MS Homo sapiens 3 LHX4   Proximity Label-MS Homo sapiens 4 TLX2   Proximity Label-MS Homo sapiens 5 TLX3   Proximity Label-MS Homo sapiens 6 PAX6   Proximity Label-MS Homo sapiens 7 MYCN   Affinity Capture-MS Homo sapiens 8 POLR2F   Affinity Capture-MS Homo sapiens 9 CCNA2 890 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 10 LHX2   Proximity Label-MS Homo sapiens 11 WDFY2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 12 FEV   Proximity Label-MS Homo sapiens 13 GSPT1 2935 Affinity Capture-MS Homo sapiens 14 LAS1L 81887 Affinity Capture-MS Homo sapiens 15 NFIB   Proximity Label-MS Homo sapiens 16 HIST2H2BE 8349 Affinity Capture-MS Homo sapiens 17 HOMEZ   Two-hybrid Homo sapiens Two-hybrid Homo sapiens 18 XPO1 7514 Affinity Capture-MS Homo sapiens 19 PTMA 5757 Affinity Capture-MS Homo sapiens 20 SOX15   Proximity Label-MS Homo sapiens 21 DNTTIP1 116092 Co-fractionation Homo sapiens Co-fractionation Homo sapiens 22 FOXJ2   Affinity Capture-MS Homo sapiens 23 ZNF217 7764 Co-fractionation Homo sapiens 24 RPA2 6118 Affinity Capture-MS Homo sapiens 25 HDAC2 3066 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 26 RPA1 6117 Affinity Capture-MS Homo sapiens 27 TRERF1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 28 PAX2   Proximity Label-MS Homo sapiens 29 PAX9   Proximity Label-MS Homo sapiens 30 TFAP4 7023 Affinity Capture-MS Homo sapiens 31 HIST1H4A 8359 Affinity Capture-MS Homo sapiens 32 SOX17   Proximity Label-MS Homo sapiens 33 SP7   Proximity Label-MS Homo sapiens 34 SH3RF2   Affinity Capture-MS Homo sapiens 35 PLK2   Affinity Capture-MS Homo sapiens 36 PHOSPHO2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 37 TBR1   Proximity Label-MS Homo sapiens 38 SOX2   Proximity Label-MS Homo sapiens 39 ELMSAN1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Co-fractionation Homo sapiens Affinity Capture-MS Homo sapiens 40 HDAC1 3065 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 41 STK11 6794 Negative Genetic Homo sapiens 42 HNF4A   Proximity Label-MS Homo sapiens 43 TRIM55   Two-hybrid Homo sapiens 44 KDM1A 23028 Two-hybrid Homo sapiens 45 CDC16 8881 Affinity Capture-MS Homo sapiens 46 MFAP1   Two-hybrid Homo sapiens 47 ABTB1   Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 48 NEFM 4741 Affinity Capture-MS Homo sapiens 49 RPA3 6119 Affinity Capture-MS Homo sapiens 50 DNTT 1791 Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Co-fractionation Homo sapiens 51 IRF8   Proximity Label-MS Homo sapiens 52 SAP30 8819 Co-fractionation Homo sapiens 53 EAF1   Two-hybrid Homo sapiens 54 WIBG 84305 Co-fractionation Homo sapiens 55 HMBOX1   Two-hybrid Homo sapiens 56 ANP32B 10541 Two-hybrid Homo sapiens 57 Mms19   Affinity Capture-MS Mus musculus 58 PAX8   Proximity Label-MS Homo sapiens 59 ERG   Proximity Label-MS Homo sapiens 60 MAGEA6   Two-hybrid Homo sapiens 61 HNF1B   Proximity Label-MS Homo sapiens 62 PARP1 142 Affinity Capture-MS Homo sapiens 63 AR 367 Proximity Label-MS Homo sapiens 64 GATA2   Proximity Label-MS Homo sapiens 65 EIF2S1 1965 Co-fractionation Homo sapiens 66 GCM1   Proximity Label-MS Homo sapiens 67 PAX7   Proximity Label-MS Homo sapiens 68 CEBPA   Proximity Label-MS Homo sapiens 69 NANOG   Affinity Capture-MS Homo sapiens 70 Set 56086 Affinity Capture-MS Mus musculus 71 CLCN2   Affinity Capture-MS Homo sapiens 72 PPM1G 5496 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 73 KLF3   Proximity Label-MS Homo sapiens 74 TRIM63   Two-hybrid Homo sapiens View the network

Pathways in which DNTTIP1 is involved

No pathways found