Gene description for DNTTIP1
Gene name deoxynucleotidyltransferase, terminal, interacting protein 1
Gene symbol DNTTIP1
Other names/aliases C20orf167
Tdif1
dJ447F3.4
Species Homo sapiens
 Database cross references - DNTTIP1
ExoCarta ExoCarta_116092
Entrez Gene 116092
HGNC 16160
MIM 611388
UniProt Q9H147  
 DNTTIP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for DNTTIP1
Molecular Function
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    nucleosome binding GO:0031491 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    histone deacetylase complex GO:0000118 IDA
 Experiment description of studies that identified DNTTIP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DNTTIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNTTIP1 is involved
No pathways found





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