Gene description for IL1RN
Gene name interleukin 1 receptor antagonist
Gene symbol IL1RN
Other names/aliases DIRA
ICIL-1RA
IL-1RN
IL-1ra
IL-1ra3
IL1F3
IL1RA
IRAP
MVCD4
Species Homo sapiens
 Database cross references - IL1RN
ExoCarta ExoCarta_3557
Vesiclepedia VP_3557
Entrez Gene 3557
HGNC 6000
MIM 147679
UniProt P18510  
 IL1RN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for IL1RN
Molecular Function
    interleukin-1 Type II receptor antagonist activity GO:0045353 IDA
    interleukin-1 receptor antagonist activity GO:0005152 TAS
    interleukin-1 receptor binding GO:0005149 IDA
    interleukin-1, Type I receptor binding GO:0005150 IPI
    interleukin-1 Type I receptor antagonist activity GO:0045352 IDA
    cytokine activity GO:0005125 IBA
    interleukin-1, Type II receptor binding GO:0005151 IPI
Biological Process
    cytokine-mediated signaling pathway GO:0019221 IBA
    response to interleukin-4 GO:0070670 IEA
    female pregnancy GO:0007565 IEA
    response to interleukin-1 GO:0070555 IEA
    carboxylic acid metabolic process GO:0019752 IEA
    response to starvation GO:0042594 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    fever generation GO:0001660 IEA
    positive regulation of JUN kinase activity GO:0043507 IEA
    chronic inflammatory response to antigenic stimulus GO:0002439 IEA
    negative regulation of interleukin-1-mediated signaling pathway GO:2000660 IDA
    response to drug GO:0042493 IEA
    negative regulation of heterotypic cell-cell adhesion GO:0034115 IDA
    negative regulation of glutamate secretion GO:0014050 IEA
    response to lipopolysaccharide GO:0032496 IEA
    cellular response to norepinephrine stimulus GO:0071874 IEA
    immune response GO:0006955 NAS
    acute-phase response GO:0006953 IDA
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IDA
    memory GO:0007613 IEA
    sensory perception of pain GO:0019233 IEA
    negative regulation of membrane potential GO:0045837 IEA
    negative regulation of cell migration GO:0030336 IEA
    insulin secretion GO:0030073 IEA
    response to activity GO:0014823 IEA
    response to glucocorticoid GO:0051384 IDA
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    intracellular GO:0005622 NAS
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified IL1RN in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for IL1RN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL1R2  
Invivo Homo sapiens
2 NR3C1 2908
Affinity Capture-MS Homo sapiens
3 IL1RN 3557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TNKS 8658
Invivo Homo sapiens
Invitro Homo sapiens
5 IL1R1 3554
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which IL1RN is involved
PathwayEvidenceSource
Interleukin-1 signaling TAS Reactome





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