Gene description for ANXA8
Gene name annexin A8
Gene symbol ANXA8
Other names/aliases ANX8
Species Homo sapiens
 Database cross references - ANXA8
ExoCarta ExoCarta_653145
Entrez Gene 653145
HGNC 546
MIM 602396
UniProt P13928   Q5T2P8  
 ANXA8 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
 Gene ontology annotations for ANXA8
Molecular Function
    actin filament binding GO:0051015 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    calcium-dependent phospholipid binding GO:0005544 IDA
    calcium ion binding GO:0005509 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
Biological Process
    negative regulation of serine-type endopeptidase activity GO:1900004 IDA
    blood coagulation GO:0007596 IEA
    endosomal transport GO:0016197 IMP
    negative regulation of phospholipase A2 activity GO:1900138 IDA
    endosome organization GO:0007032 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    late endosome membrane GO:0031902 IDA
 Experiment description of studies that identified ANXA8 in exosomes
1
Experiment ID 76
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|GAPDH|HSP90
EV Cytosolic markers
✔
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
✔
HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
 Protein-protein interactions for ANXA8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANXA8 is involved
No pathways found





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