Gene description for SOX18
Gene name SRY (sex determining region Y)-box 18
Gene symbol SOX18
Other names/aliases HLTS
Species Homo sapiens
 Database cross references - SOX18
ExoCarta ExoCarta_54345
Entrez Gene 54345
HGNC 11194
MIM 601618
UniProt P35713  
 SOX18 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SOX18
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    cell maturation GO:0048469 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    angiogenesis GO:0001525 IEP
    blood vessel endothelial cell migration GO:0043534 IEP
    heart looping GO:0001947 ISS
    in utero embryonic development GO:0001701 IEA
    endocardial cell differentiation GO:0060956 ISS
    lymphangiogenesis GO:0001946 IMP
    regulation of stem cell proliferation GO:0072091 IEA
    establishment of endothelial barrier GO:0061028 IMP
    hair follicle development GO:0001942 IEA
    embryonic heart tube development GO:0035050 ISS
    endocardium formation GO:0060214 ISS
    lymphatic endothelial cell differentiation GO:0060836 ISS
    stem cell fate specification GO:0048866 IEA
    mRNA transcription from RNA polymerase II promoter GO:0042789 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    hair cycle process GO:0022405 IMP
    outflow tract morphogenesis GO:0003151 ISS
    vasculogenesis GO:0001570 ISS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    vasculature development GO:0001944 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear transcription factor complex GO:0044798 IEA
    nuclear chromatin GO:0000790 IDA
 Experiment description of studies that identified SOX18 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SOX18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEF2C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SOX18 is involved
No pathways found





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