Gene description for SOX18
Gene name SRY (sex determining region Y)-box 18
Gene symbol SOX18
Other names/aliases HLTS
Species Homo sapiens
 Database cross references - SOX18
ExoCarta ExoCarta_54345
Vesiclepedia VP_54345
Entrez Gene 54345
HGNC 11194
MIM 601618
UniProt P35713  
 SOX18 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SOX18
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    angiogenesis GO:0001525 IBA
    angiogenesis GO:0001525 IEP
    vasculogenesis GO:0001570 IBA
    vasculogenesis GO:0001570 ISS
    in utero embryonic development GO:0001701 IEA
    hair follicle development GO:0001942 IEA
    vasculature development GO:0001944 ISS
    lymphangiogenesis GO:0001946 IBA
    lymphangiogenesis GO:0001946 IMP
    heart looping GO:0001947 ISS
    outflow tract morphogenesis GO:0003151 ISS
    hair cycle process GO:0022405 IMP
    embryonic heart tube development GO:0035050 ISS
    blood vessel endothelial cell migration GO:0043534 IEP
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    cell maturation GO:0048469 IEA
    stem cell fate specification GO:0048866 IEA
    endocardium formation GO:0060214 ISS
    lymphatic endothelial cell differentiation GO:0060836 ISS
    endocardial cell differentiation GO:0060956 ISS
    establishment of endothelial barrier GO:0061028 IMP
    regulation of stem cell proliferation GO:0072091 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    transcription regulator complex GO:0005667 IEA
 Experiment description of studies that identified SOX18 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SOX18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MECP2 4204
Two-hybrid Homo sapiens
2 STK11 6794
Negative Genetic Homo sapiens
3 MEF2C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 GKAP1  
Two-hybrid Homo sapiens
5 AURKA 6790
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SOX18 is involved
No pathways found





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