Gene description for YPEL5
Gene name yippee-like 5 (Drosophila)
Gene symbol YPEL5
Other names/aliases CGI-127
Species Homo sapiens
 Database cross references - YPEL5
ExoCarta ExoCarta_51646
Vesiclepedia VP_51646
Entrez Gene 51646
HGNC 18329
MIM 609726
UniProt P62699  
 YPEL5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for YPEL5
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    cell population proliferation GO:0008283 ISS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    ubiquitin ligase complex GO:0000151 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 ISS
    centrosome GO:0005813 ISS
    midbody GO:0030496 ISS
    mitotic spindle pole GO:0097431 ISS
    tertiary granule lumen GO:1904724 TAS
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified YPEL5 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for YPEL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SHC3  
Two-hybrid Homo sapiens
3 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MRPL4 51073
Affinity Capture-MS Homo sapiens
5 EFHC2  
Affinity Capture-MS Homo sapiens
6 CBFA2T3  
Affinity Capture-MS Homo sapiens
7 RAB8A 4218
Affinity Capture-MS Homo sapiens
8 KCTD6  
Affinity Capture-MS Homo sapiens
9 MRPS2 51116
Affinity Capture-MS Homo sapiens
10 NMB  
Affinity Capture-MS Homo sapiens
11 JPH4 84502
Affinity Capture-MS Homo sapiens
12 PLAGL2  
Two-hybrid Homo sapiens
13 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
14 GLB1 2720
Affinity Capture-MS Homo sapiens
15 PBRM1 55193
Negative Genetic Homo sapiens
16 EPB41L5 57669
Affinity Capture-MS Homo sapiens
17 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RMND5B  
Affinity Capture-MS Homo sapiens
19 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
20 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
21 IKZF1  
Affinity Capture-MS Homo sapiens
22 ARMC8 25852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ECHS1 1892
Affinity Capture-MS Homo sapiens
24 GDF15 9518
Affinity Capture-MS Homo sapiens
25 DUSP27  
Affinity Capture-MS Homo sapiens
26 AMOTL1 154810
Affinity Capture-MS Homo sapiens
27 MRPS28  
Affinity Capture-MS Homo sapiens
28 DDIT4L  
Two-hybrid Homo sapiens
29 ZNF655  
Two-hybrid Homo sapiens
30 RANBP9 10048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CTSA 5476
Affinity Capture-MS Homo sapiens
32 GID8 54994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TRIM28 10155
Affinity Capture-MS Homo sapiens
34 PSMA1 5682
Two-hybrid Homo sapiens
35 CORO2A  
Affinity Capture-MS Homo sapiens
36 DDX5 1655
Affinity Capture-MS Homo sapiens
37 WDR26 80232
Affinity Capture-MS Homo sapiens
38 EMILIN3  
Affinity Capture-MS Homo sapiens
39 LECT2  
Affinity Capture-MS Homo sapiens
40 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
41 GNLY  
Affinity Capture-MS Homo sapiens
42 STK11 6794
Negative Genetic Homo sapiens
43 RMND5A 64795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MRPS24 64951
Affinity Capture-MS Homo sapiens
45 GDNF  
Affinity Capture-MS Homo sapiens
46 TDGF1  
Affinity Capture-MS Homo sapiens
47 WNT10A  
Affinity Capture-MS Homo sapiens
48 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
49 ADCYAP1  
Affinity Capture-MS Homo sapiens
50 GCG  
Affinity Capture-MS Homo sapiens
51 MKLN1  
Affinity Capture-MS Homo sapiens
52 CTDSP1 58190
Two-hybrid Homo sapiens
53 MAPKBP1  
Two-hybrid Homo sapiens
54 PFDN5 5204
Two-hybrid Homo sapiens
55 C2orf44  
Affinity Capture-MS Homo sapiens
56 MRPL18 29074
Affinity Capture-MS Homo sapiens
57 RANBP10 57610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 MAEA 10296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 GPS2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which YPEL5 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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