Gene description for RPS6KB1
Gene name ribosomal protein S6 kinase, 70kDa, polypeptide 1
Gene symbol RPS6KB1
Other names/aliases PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70 S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
Species Homo sapiens
 Database cross references - RPS6KB1
ExoCarta ExoCarta_6198
Vesiclepedia VP_6198
Entrez Gene 6198
HGNC 10436
MIM 608938
UniProt P23443  
 RPS6KB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RPS6KB1
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    peptide binding GO:0042277 IEA
    ribosomal protein S6 kinase activity GO:0004711 IBA
    protein kinase activity GO:0004672 IDA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IDA
Biological Process
    signal transduction GO:0007165 TAS
    germ cell development GO:0007281 IEA
    positive regulation of translation GO:0045727 IMP
    response to glucose GO:0009749 IEA
    skeletal muscle contraction GO:0003009 IEA
    response to electrical stimulus involved in regulation of muscle adaptation GO:0014878 IEA
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    response to lipopolysaccharide GO:0032496 IEA
    response to drug GO:0042493 IEA
    TOR signaling GO:0031929 IDA
    protein kinase B signaling GO:0043491 IEA
    response to nutrient GO:0007584 IEA
    response to testosterone GO:0033574 IEA
    response to glucagon GO:0033762 IEA
    long-term memory GO:0007616 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    positive regulation of mitotic cell cycle GO:0045931 IMP
    protein phosphorylation GO:0006468 IEA
    skeletal muscle atrophy GO:0014732 IEA
    response to ethanol GO:0045471 IEA
    response to glucocorticoid GO:0051384 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    response to heat GO:0009408 IEA
    cell migration GO:0016477 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of skeletal muscle tissue growth GO:0048633 IEA
    response to leucine GO:0043201 IEA
    cellular response to insulin stimulus GO:0032869 IBA
    regulation of glucose import GO:0046324 IEA
    apoptotic process GO:0006915 IEA
    response to mechanical stimulus GO:0009612 IEA
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    positive regulation of translational initiation GO:0045948 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    response to wounding GO:0009611 IEA
    response to tumor necrosis factor GO:0034612 IEA
    cellular response to growth factor stimulus GO:0071363 IDA
    response to toxic substance GO:0009636 IEA
    aging GO:0007568 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    cell junction GO:0030054 IEA
    neuron projection GO:0043005 IEA
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IDA
    cell surface GO:0009986 IEA
    mitochondrial outer membrane GO:0005741 IEA
    nucleoplasm GO:0005654 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified RPS6KB1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RPS6KB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TERT  
Affinity Capture-Western Homo sapiens
2 GDI2P  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
3 EIF3F 8665
Affinity Capture-MS Homo sapiens
4 POLDIP3 84271
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 COASY 80347
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 CSNK2B 1460
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 EIF3C 8663
Affinity Capture-Western Homo sapiens
8 XPO1 7514
Affinity Capture-Western Homo sapiens
9 TRAF4 9618
Affinity Capture-Western Homo sapiens
10 PDK1 5163
Reconstituted Complex Homo sapiens
11 PRKCZ 5590
Affinity Capture-Western Homo sapiens
12 RPTOR 57521
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 RICTOR 253260
Reconstituted Complex Homo sapiens
14 CSNK2A1 1457
Reconstituted Complex Homo sapiens
15 LYN 4067
Biochemical Activity Homo sapiens
16 Xpo1 103573
Affinity Capture-Western Mus musculus
17 ACTA1 58
Reconstituted Complex Homo sapiens
18 MTOR 2475
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 EIF3B 8662
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 SYK 6850
Biochemical Activity Homo sapiens
21 SRC 6714
Biochemical Activity Homo sapiens
22 BTK 695
Biochemical Activity Homo sapiens
23 AKT1 207
Co-purification Homo sapiens
24 PPP2R2A 5520
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 EEF2K  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RPS6KB1 is involved
PathwayEvidenceSource
S6K1 signalling TAS Reactome
S6K1 signalling TAS Reactome
S6K1-mediated signalling TAS Reactome
S6K1-mediated signalling TAS Reactome





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