Gene description for GDA
Gene name guanine deaminase
Gene symbol GDA
Other names/aliases CYPIN
GUANASE
NEDASIN
Species Homo sapiens
 Database cross references - GDA
ExoCarta ExoCarta_9615
Entrez Gene 9615
HGNC 4212
MIM 139260
UniProt Q9Y2T3  
 GDA identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for GDA
Molecular Function
    guanine deaminase activity GO:0008892 EXP
    zinc ion binding GO:0008270 IEA
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    guanine catabolic process GO:0006147 IEA
    nervous system development GO:0007399 TAS
    purine nucleotide catabolic process GO:0006195 TAS
    purine nucleobase metabolic process GO:0006144 TAS
    small molecule metabolic process GO:0044281 TAS
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    intracellular GO:0005622 TAS
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GDA in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GDA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLG4  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 DLG1 1739
Invivo Homo sapiens
3 DLG3 1741
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GDA is involved
PathwayEvidenceSource
Purine catabolism TAS Reactome





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