Gene description for BCCIP
Gene name BRCA2 and CDKN1A interacting protein
Gene symbol BCCIP
Other names/aliases TOK-1
Species Homo sapiens
 Database cross references - BCCIP
ExoCarta ExoCarta_56647
Entrez Gene 56647
HGNC 978
MIM 611883
UniProt Q9P287  
 BCCIP identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for BCCIP
Molecular Function
    kinase regulator activity GO:0019207 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    neuroendocrine cell differentiation GO:0061101 IDA
    DNA repair GO:0006281 IEA
    cell cycle GO:0007049 IEA
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IDA
Subcellular Localization
    nuclear cyclin-dependent protein kinase holoenzyme complex GO:0019908 IDA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified BCCIP in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BCCIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTN  
Two-hybrid Homo sapiens
2 ITSN2 50618
Two-hybrid Homo sapiens
3 BRCA2 675
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 CDK2 1017
Affinity Capture-Western Homo sapiens
5 HIST1H2BN 8341
Two-hybrid Homo sapiens
6 CDKN1A  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 CAPZB 832
Two-hybrid Homo sapiens
8 RPL23 9349
Two-hybrid Homo sapiens
9 EIF6 3692
Affinity Capture-MS Homo sapiens
10 FAM46A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCCIP is involved
No pathways found

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