Gene description for PAPD4
Gene name PAP associated domain containing 4
Gene symbol PAPD4
Other names/aliases GLD2
TUT2
Species Homo sapiens
 Database cross references - PAPD4
ExoCarta ExoCarta_167153
Entrez Gene 167153
HGNC 26776
MIM 614121
UniProt Q6PIY7  
 PAPD4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PAPD4
Molecular Function
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    polynucleotide adenylyltransferase activity GO:0004652 IDA
Biological Process
    histone mRNA catabolic process GO:0071044 IMP
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    mRNA processing GO:0006397 IEA
    RNA polyadenylation GO:0043631 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nuclear RNA-directed RNA polymerase complex GO:0031380 IC
 Experiment description of studies that identified PAPD4 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PAPD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PAPD4 is involved
No pathways found





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