Gene description for PPP5C
Gene name protein phosphatase 5, catalytic subunit
Gene symbol PPP5C
Other names/aliases PP5
Species Homo sapiens
 Database cross references - PPP5C
ExoCarta ExoCarta_5536
Entrez Gene 5536
HGNC 9322
MIM 600658
UniProt P53041  
 PPP5C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PPP5C
Molecular Function
    phosphoprotein phosphatase activity GO:0004721 ISS
    protein serine/threonine phosphatase activity GO:0004722 TAS
    signal transducer activity GO:0004871 IMP
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    RNA binding GO:0003723 IEA
    metal ion binding GO:0046872 IEA
    lipid binding GO:0008289 IEA
Biological Process
    response to morphine GO:0043278 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    transcription, DNA-templated GO:0006351 TAS
    mitotic nuclear division GO:0007067 TAS
    protein heterooligomerization GO:0051291 IEA
    protein dephosphorylation GO:0006470 IEA
    DNA repair GO:0006281 IEA
    signal transduction GO:0007165 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    neuronal cell body GO:0043025 IEA
    membrane GO:0016020 IEA
    cytosol GO:0005829 IEA
    neuron projection GO:0043005 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified PPP5C in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PPP5C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRY2  
Invitro Homo sapiens
2 GNA13 10672
Reconstituted Complex Homo sapiens
3 GNA12 2768
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 MAP3K5  
Invivo Homo sapiens
Two-hybrid Homo sapiens
5 CSE1L 1434
Two-hybrid Homo sapiens
6 CDC27 996
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PPP5C is involved
No pathways found

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