Gene description for CNTLN
Gene name centlein, centrosomal protein
Gene symbol CNTLN
Other names/aliases C9orf101
C9orf39
bA340N12.1
Species Homo sapiens
 Database cross references - CNTLN
ExoCarta ExoCarta_54875
Entrez Gene 54875
HGNC 23432
MIM 611870
UniProt Q9NXG0  
 CNTLN identified in exosomes derived from the following tissue/cell type
Mesothelioma cells 15111327    
Urine 19056867    
 Gene ontology annotations for CNTLN
Molecular Function
    phosphorelay sensor kinase activity GO:0000155 IEA
    protein kinase binding GO:0019901 IPI
    protein binding, bridging GO:0030674 IMP
    protein domain specific binding GO:0019904 IPI
Biological Process
    phosphorelay signal transduction system GO:0000160 IEA
    signal transduction by protein phosphorylation GO:0023014 IEA
    centriole-centriole cohesion GO:0010457 IMP
    protein localization to organelle GO:0033365 IMP
Subcellular Localization
    centriole GO:0005814 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified CNTLN in exosomes
1
Experiment ID 25
ISEV standards
IEM
EV Biophysical techniques
HSP90|beta-tubulin
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15111327    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes secreted by human mesothelioma cells.
Authors Hegmans JP, Bard MP, Hemmes A, Luider TM, Kleijmeer MJ, Prins JB, Zitvogel L, Burgers SA, Hoogsteden HC, Lambrecht BN.
Journal name AJP
Publication year 2004
Sample Mesothelioma cells
Sample name PMR-MM7
PMR-MM8
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CNTLN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CNTLN is involved
No pathways found





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