Gene description for PRSS12
Gene name protease, serine, 12 (neurotrypsin, motopsin)
Gene symbol PRSS12
Other names/aliases BSSP-3
BSSP3
MRT1
Species Homo sapiens
 Database cross references - PRSS12
ExoCarta ExoCarta_8492
Vesiclepedia VP_8492
Entrez Gene 8492
HGNC 9477
MIM 606709
UniProt P56730  
 PRSS12 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PRSS12
Molecular Function
    scavenger receptor activity GO:0005044 IEA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    receptor-mediated endocytosis GO:0006898 IEA
    exocytosis GO:0006887 ISS
    zymogen activation GO:0031638 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    axon GO:0030424 ISS
    terminal bouton GO:0043195 IEA
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 ISS
    dendrite GO:0030425 IEA
    synaptic cleft GO:0043083 IEA
 Experiment description of studies that identified PRSS12 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PRSS12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRSS12 is involved
No pathways found





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