Gene description for USP49
Gene name ubiquitin specific peptidase 49
Gene symbol USP49
Other names/aliases -
Species Homo sapiens
 Database cross references - USP49
ExoCarta ExoCarta_25862
Entrez Gene 25862
HGNC 20078
UniProt Q70CQ1  
 USP49 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for USP49
Molecular Function
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IDA
    ubiquitin-specific protease activity GO:0004843 IDA
    zinc ion binding GO:0008270 IEA
    cysteine-type endopeptidase activity GO:0004197 IMP
Biological Process
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    histone H2B conserved C-terminal lysine deubiquitination GO:0035616 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein deubiquitination GO:0016579 IDA
    mRNA splicing, via spliceosome GO:0000398 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified USP49 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP49
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which USP49 is involved
No pathways found

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