Gene description for PDCD2
Gene name programmed cell death 2
Gene symbol PDCD2
Other names/aliases RP8
ZMYND7
Species Homo sapiens
 Database cross references - PDCD2
ExoCarta ExoCarta_5134
Entrez Gene 5134
HGNC 8762
MIM 600866
UniProt Q16342  
 PDCD2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PDCD2
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    metal ion binding GO:0046872 IEA
    DNA binding GO:0003677 IEA
Biological Process
    apoptotic process GO:0006915 TAS
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    regulation of hematopoietic progenitor cell differentiation GO:1901532 IMP
    positive regulation of hematopoietic stem cell proliferation GO:1902035 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified PDCD2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PDCD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HCFC1 3054
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 NCOR1  
Affinity Capture-Western Homo sapiens
3 LSM8  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PDCD2 is involved
No pathways found





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