Gene description for LSM8
Gene name LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Gene symbol LSM8
Other names/aliases NAA38
Species Homo sapiens
 Database cross references - LSM8
ExoCarta ExoCarta_51691
Vesiclepedia VP_51691
Entrez Gene 51691
HGNC 20471
MIM 607288
UniProt O95777  
 LSM8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LSM8
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    U6 snRNA binding GO:0017070 NAS
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
Subcellular Localization
    spliceosomal complex GO:0005681 IEA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
 Experiment description of studies that identified LSM8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LSM8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASK  
Two-hybrid Homo sapiens
2 NAGK 55577
Two-hybrid Homo sapiens
3 EXOSC6 118460
Two-hybrid Homo sapiens
4 MTHFR 4524
Two-hybrid Homo sapiens
5 THUMPD3 25917
Two-hybrid Homo sapiens
6 GTF2I 2969
Two-hybrid Homo sapiens
7 TALDO1 6888
Two-hybrid Homo sapiens
8 ISOC2  
Two-hybrid Homo sapiens
9 SEPT5 5413
Two-hybrid Homo sapiens
10 LSM4 25804
Invitro Homo sapiens
11 IL28RA  
Two-hybrid Homo sapiens
12 PDCD2 5134
Two-hybrid Homo sapiens
13 LSM5 23658
Invitro Homo sapiens
14 FAM63A 55793
Two-hybrid Homo sapiens
15 LSM7  
Invitro Homo sapiens
16 ITSN2 50618
Two-hybrid Homo sapiens
17 FERMT3 83706
Two-hybrid Homo sapiens
18 SNRPD1 6632
Two-hybrid Homo sapiens
19 IGHMBP2 3508
Two-hybrid Homo sapiens
20 PGD 5226
Two-hybrid Homo sapiens
21 UPF1 5976
Two-hybrid Homo sapiens
22 DCP1A 55802
Two-hybrid Homo sapiens
23 LSM6 11157
Invitro Homo sapiens
24 LSM2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 KCTD3  
Two-hybrid Homo sapiens
26 LSM3 27258
Invitro Homo sapiens
27 COL23A1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LSM8 is involved
No pathways found





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